biostudies-literatureHamilton PWNEI NIH HHS206-215https://www.ebi.ac.uk/biostudies/studies/S-EPMC4842149biostudies-literatureUnknown145The frog, Xenopus laevis, possesses a high capacity to regenerate various larval tissues, including the lens, which is capable of complete regeneration from the cornea epithelium. However, the molecular signaling mechanisms of cornea-lens regeneration are not fully understood. Previous work has implicated the involvement of the Wnt signaling pathway, but molecular studies have been very limited. Iris-derived lens regeneration in the newt (Wolffian lens regeneration) has shown a necessity for active Wnt signaling in order to regenerate a new lens. Here we provide evidence that the Wnt signaling pathway plays a different role in the context of cornea-lens regeneration in Xenopus. We examined the expression of frizzled receptors and wnt ligands in the frog cornea epithelium. Numerous frizzledExperimental eye researchLens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.PMC4842149R01 EY009844R01 EY023979Henry JJHamilton PWSun YfalseLens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.The frog, Xenopus laevis, possesses a high capacity to regenerate various larval tissues, including the lens, which is capable of complete regeneration from the cornea epithelium. However, the molecular signaling mechanisms of cornea-lens regeneration are not fully understood. Previous work has implicated the involvement of the Wnt signaling pathway, but molecular studies have been very limited. Iris-derived lens regeneration in the newt (Wolffian lens regeneration) has shown a necessity for active Wnt signaling in order to regenerate a new lens. Here we provide evidence that the Wnt signaling pathway plays a different role in the context of cornea-lens regeneration in Xenopus. We examined the expression of frizzled receptors and wnt ligands in the frog cornea epithelium. Numerous frizzled2016-01-01T00:00:00Z2016 Apr2025-04-29T10:14:19.747Z2019-03-27T02:12:16ZS-EPMC48421492677874910.1016/j.exer.2016.01.003