{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nehls EM"],"funding":["NIDCR NIH HHS","Howard Hughes Medical Institute","Burroughs Wellcome Fund","National Heart, Lung, and Blood Institute","NHLBI NIH HHS","National Science Foundation"],"pagination":["1035-1039"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4843523"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(6)"],"pubmed_abstract":["We present a versatile and facile method to enhance user-control of small molecule drug release from a poly(ethylene glycol)-based hydrogel using the host/guest complex formed between an azobenzene derivative guest and a β-cyclodextrin host. A model drug is formed from a short peptide containing a fluorophore and an azobenzene functional group on one terminus. Upon irradiation with UV light, azobenzene isomerization leads to decreased complex formation and an on-demand acceleratation of the release rate of an entrapped model drug."],"journal":["Journal of materials chemistry. B"],"pubmed_title":["Enhanced User-Control of Small Molecule Drug Release from a Poly(ethylene glycol) Hydrogel via Azobenzene/Cyclodextrin Complex Tethers."],"pmcid":["PMC4843523"],"funding_grant_id":["DMR 1408955","1013981","5 F32 HL121986-02","R01 DE016523","F32 HL121986"],"pubmed_authors":["Rosales AM","Anseth KS","Nehls EM"],"additional_accession":[]},"is_claimable":false,"name":"Enhanced User-Control of Small Molecule Drug Release from a Poly(ethylene glycol) Hydrogel via Azobenzene/Cyclodextrin Complex Tethers.","description":"We present a versatile and facile method to enhance user-control of small molecule drug release from a poly(ethylene glycol)-based hydrogel using the host/guest complex formed between an azobenzene derivative guest and a β-cyclodextrin host. A model drug is formed from a short peptide containing a fluorophore and an azobenzene functional group on one terminus. Upon irradiation with UV light, azobenzene isomerization leads to decreased complex formation and an on-demand acceleratation of the release rate of an entrapped model drug.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-04-29T10:10:37.455Z","creation":"2019-03-27T02:12:20Z"},"accession":"S-EPMC4843523","cross_references":{"pubmed":["27127630"],"doi":["10.1039/c5tb02004b","10.1039/C5TB02004B"]}}