biostudies-literatureNehls EMNIDCR NIH HHSHoward Hughes Medical InstituteBurroughs Wellcome FundNational Heart, Lung, and Blood InstituteNHLBI NIH HHSNational Science Foundation1035-1039https://www.ebi.ac.uk/biostudies/studies/S-EPMC4843523biostudies-literatureUnknown4(6)We present a versatile and facile method to enhance user-control of small molecule drug release from a poly(ethylene glycol)-based hydrogel using the host/guest complex formed between an azobenzene derivative guest and a β-cyclodextrin host. A model drug is formed from a short peptide containing a fluorophore and an azobenzene functional group on one terminus. Upon irradiation with UV light, azobenzene isomerization leads to decreased complex formation and an on-demand acceleratation of the release rate of an entrapped model drug.Journal of materials chemistry. BEnhanced User-Control of Small Molecule Drug Release from a Poly(ethylene glycol) Hydrogel via Azobenzene/Cyclodextrin Complex Tethers.PMC4843523DMR 140895510139815 F32 HL121986-02R01 DE016523F32 HL121986Rosales AMAnseth KSNehls EMfalseEnhanced User-Control of Small Molecule Drug Release from a Poly(ethylene glycol) Hydrogel via Azobenzene/Cyclodextrin Complex Tethers.We present a versatile and facile method to enhance user-control of small molecule drug release from a poly(ethylene glycol)-based hydrogel using the host/guest complex formed between an azobenzene derivative guest and a β-cyclodextrin host. A model drug is formed from a short peptide containing a fluorophore and an azobenzene functional group on one terminus. Upon irradiation with UV light, azobenzene isomerization leads to decreased complex formation and an on-demand acceleratation of the release rate of an entrapped model drug.2016-01-01T00:00:00Z20162025-04-29T10:10:37.455Z2019-03-27T02:12:20ZS-EPMC48435232712763010.1039/c5tb02004b10.1039/C5TB02004B