{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Burslem GM"],"funding":["European Research Council","AstraZeneca","Biotechnology and Biological Sciences Research Council","Engineering and Physical Sciences Research Council"],"pagination":["5421-4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4843846"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(31)"],"pubmed_abstract":["Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1α from which it is derived."],"journal":["Chemical communications (Cambridge, England)"],"pubmed_title":["Towards \"bionic\" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics."],"pmcid":["PMC4843846"],"funding_grant_id":["ERC-StG-240324","ERC-PoC 632207","BB/L015056/1"],"pubmed_authors":["Burslem GM","Edwards TA","Kyle HF","Nelson A","Wilson AJ","Warriner SL","Breeze AL"],"additional_accession":[]},"is_claimable":false,"name":"Towards \"bionic\" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics.","description":"Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1α from which it is derived.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2025-04-04T00:35:55.009Z","creation":"2019-03-27T02:12:19Z"},"accession":"S-EPMC4843846","cross_references":{"pubmed":["27009828"],"doi":["10.1039/c6cc01812b"]}}