biostudies-literatureBurslem GMEuropean Research CouncilAstraZenecaBiotechnology and Biological Sciences Research CouncilEngineering and Physical Sciences Research Council5421-4https://www.ebi.ac.uk/biostudies/studies/S-EPMC4843846biostudies-literatureUnknown52(31)Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1α from which it is derived.Chemical communications (Cambridge, England)Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics.PMC4843846ERC-StG-240324ERC-PoC 632207BB/L015056/1Burslem GMEdwards TAKyle HFNelson AWilson AJWarriner SLBreeze ALfalseTowards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics.Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1α from which it is derived.2016-01-01T00:00:00Z2016 Apr2025-04-04T00:35:55.009Z2019-03-27T02:12:19ZS-EPMC48438462700982810.1039/c6cc01812b