{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu W"],"funding":["NIA NIH HHS"],"pagination":["24480"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4846810"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["Phosphatidylinositolbinding clathrin assembly protein (PICALM) gene is one novel genetic player associated with late-onset Alzheimer's disease (LOAD), based on recent genome wide association studies (GWAS). However, how it affects AD occurrence is still unknown. Brain reserve hypothesis highlights the tolerant capacities of brain as a passive means to fight against neurodegenerations. Here, we took the baseline volume and/or thickness of LOAD-associated brain regions as proxies of brain reserve capacities and investigated whether PICALM genetic variations can influence the baseline reserve capacities and the longitudinal atrophy rate of these specific regions using data from Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. In mixed population, we found that brain region signific"],"journal":["Scientific reports"],"pubmed_title":["The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum."],"pmcid":["PMC4846810"],"funding_grant_id":["U24 AG021886","P50 AG005142","U01 AG024904"],"pubmed_authors":["Carmichael O","Belden CM","Taylor JL","Grossman H","Brewer J","Rosen HJ","Lane B","Chertkow H","DeCarli C","Wang HF","Lord JL","Bonakdarpour B","Kendall T","Alzheimer’s Disease Neuroimaging Initiative Group","Villanueva-Meyer J","Petrella JR","Woo E","Roberson E","Creech ML","Geldmacher D","Duara R","Watkins F","Reeder S","Pasternack S","de Leon MJ","Oates E","Celmins D","Wu CK","Pawluczyk S","Fletcher E","Lah JJ","Xu W","Lin M","Munic D","Salloway S","Tan MS","Mintun MA","Capote H","Feldman H","Dang M","Johnson KA","Lee TY","Doraiswamy PM","Bernick C","Preda A","Asthana S","Weintraub S","Aisen P","Hosein C","Ott BR","Burns JM","Brockington J","MacAvoy MG","Quinn J","Chaing G","Smith CD","Mintzer J","Roberts P","Swerdlow RH","Tremont G","Hynes ML","Fargher K","Brosch JR","Varon D","Borges-Neto S","Hunt C","Jicha G","Carter R","Reynolds B","Kowall N","Green RC","Burke A","deToledo-Morrell L","Brand C","Silverman DH","Ravdin L","Bell KL","Teodoro L","Sirrel SA","Jacobson SA","Carlsson CM","Zimmerman EA","Pomara N","Fleisher A","Sadowsky C","Porsteinsson AP","Tingus K","Miller BL","Johnson K","Franklin E","Johnson N","Johnson S","Jiang T","Rusinek H","Robin Hsiung GY","Kertesz A","Honig LS","Shah RC","Lerner A","Morris J","Kerwin D","Lind B","Villena T","Johnson H","Bachman D","Jagust W","Saykin AJ","Mason SS","Heidebrink JL","Rosen A","Scharre DW","Albert M","Anderson K","Apostolova L","Rachisky I","Potkin SG","Albers CS","Kittur S","Finger E","Petersen R","Oliver A","Budson AE","Clark D","Scott Turner R","Tinklenberg J","Onyike C","Vanderswag H","Ismail MS","Martin K","Varma P","Spann BM","Stern Y","Greig MT","Bartzokis G","Kaye J","Fatica P","Coleman E","Bartha R","Mitsis E","Yu WJ","Norbash A","Tatsuoka C","Trost D","Conrad G","Kielb S","Knopman D","Maillard P","Adeli A","Killiany R","Kataki M","Quiceno M","Zhu XC","Silbert L","Toga AW","Galvin JE","D'Agostino D","Santulli RB","Sabbagh MN","Flashman LA","Hake AM","Yesavage J","Schneider S","Beccera M","Gordineer L","Ashok Raj B","Sarrael A","Blank K","Relkin N","Sperling RA","Carson RE","Lynn Johnson P","Brooks WM","Black S","Rainka M","Caldwell C","Pearlson GD","Farlow MR","Mudge B","Beckett L","Carroll M","Jack CR","Herring S","Mesulam MM","Lipowski K","Graff-Radford NR","Dolen S","Wolday S","Pogorelec DM","Ogrocki P","van Dyck CH","Querfurth H","Hernando R","Tan L","Mulnard RA","Stefanovic B","Malloy P","Griffith R","Bates V","Lu PH","Garg P","Mc-Adams-Ortiz C","Marson D","Wong TZ","Sinha P","Glodzik L","Yu JT","Weiner MW","Williamson JD","De Santi S","Correia S","Tan CC","Womack K","Hardy P","Michel CA","Mathews D","Cerbone B","Matthews BR","Ances B","Doody RS","Chowdhury M","Brown AD","Miao D","Borrie M","Bergman H","Olichney J","Trncic N","Seltzer M","Thai G","Makino KM","Perry D","Cellar JS","Schneider LS","Spicer K","Levey AI","Obisesan TO","Smith A","Trojanowki JQ","Marshall G","Parfitt F","Morris JC","Rountree S","Nguyen D","Allard J","Assaly M","Tariot P","Goldstein BS","Shaw LM","Sink KM","Natelson Love M"],"additional_accession":[]},"is_claimable":false,"name":"The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum.","description":"Phosphatidylinositolbinding clathrin assembly protein (PICALM) gene is one novel genetic player associated with late-onset Alzheimer's disease (LOAD), based on recent genome wide association studies (GWAS). However, how it affects AD occurrence is still unknown. Brain reserve hypothesis highlights the tolerant capacities of brain as a passive means to fight against neurodegenerations. Here, we took the baseline volume and/or thickness of LOAD-associated brain regions as proxies of brain reserve capacities and investigated whether PICALM genetic variations can influence the baseline reserve capacities and the longitudinal atrophy rate of these specific regions using data from Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. In mixed population, we found that brain region signific","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2026-05-30T09:06:17.949Z","creation":"2019-03-27T02:12:30Z"},"accession":"S-EPMC4846810","cross_references":{"pubmed":["27117083"],"doi":["10.1038/srep24480"]}}