{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lauterstein DE"],"funding":["NIEHS NIH HHS"],"pagination":["417"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4847079"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["Electronic cigarettes (e-cigarettes), battery-powered devices containing nicotine, glycerin, propylene glycol, flavorings, and other substances, are increasing in popularity. They pose a potential threat to the developing brain, as nicotine is a known neurotoxicant. We hypothesized that exposure to e-cigarettes during early life stages induce changes in central nervous system (CNS) transcriptome associated with adverse neurobiological outcomes and long-term disease states. To test the hypothesis, pregnant C57BL/6 mice were exposed daily (via whole body inhalation) throughout gestation (3 h/day; 5 days/week) to aerosols produced from e-cigarettes either with nicotine (13-16 mg/mL) or without nicotine; following birth, pups and dams were exposed together to e-cigarette aerosols throughout la"],"journal":["International journal of environmental research and public health"],"pubmed_title":["Frontal Cortex Transcriptome Analysis of Mice Exposed to Electronic Cigarettes During Early Life Stages."],"pmcid":["PMC4847079"],"funding_grant_id":["P30ES000260-50","P30 ES000260"],"pubmed_authors":["Zelikoff JT","Lauterstein DE","Corbett K","Gordon T","Klein CB","Akgol Oksuz B","Tijerina PB","Shen SS"],"additional_accession":[]},"is_claimable":false,"name":"Frontal Cortex Transcriptome Analysis of Mice Exposed to Electronic Cigarettes During Early Life Stages.","description":"Electronic cigarettes (e-cigarettes), battery-powered devices containing nicotine, glycerin, propylene glycol, flavorings, and other substances, are increasing in popularity. They pose a potential threat to the developing brain, as nicotine is a known neurotoxicant. We hypothesized that exposure to e-cigarettes during early life stages induce changes in central nervous system (CNS) transcriptome associated with adverse neurobiological outcomes and long-term disease states. To test the hypothesis, pregnant C57BL/6 mice were exposed daily (via whole body inhalation) throughout gestation (3 h/day; 5 days/week) to aerosols produced from e-cigarettes either with nicotine (13-16 mg/mL) or without nicotine; following birth, pups and dams were exposed together to e-cigarette aerosols throughout la","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2025-04-26T10:52:13.424Z","creation":"2019-03-26T22:35:20Z"},"accession":"S-EPMC4847079","cross_references":{"pubmed":["27077873"],"doi":["10.3390/ijerph13040417"]}}