biostudies-literatureLauterstein DENIEHS NIH HHS417https://www.ebi.ac.uk/biostudies/studies/S-EPMC4847079biostudies-literatureUnknown13(4)Electronic cigarettes (e-cigarettes), battery-powered devices containing nicotine, glycerin, propylene glycol, flavorings, and other substances, are increasing in popularity. They pose a potential threat to the developing brain, as nicotine is a known neurotoxicant. We hypothesized that exposure to e-cigarettes during early life stages induce changes in central nervous system (CNS) transcriptome associated with adverse neurobiological outcomes and long-term disease states. To test the hypothesis, pregnant C57BL/6 mice were exposed daily (via whole body inhalation) throughout gestation (3 h/day; 5 days/week) to aerosols produced from e-cigarettes either with nicotine (13-16 mg/mL) or without nicotine; following birth, pups and dams were exposed together to e-cigarette aerosols throughout laInternational journal of environmental research and public healthFrontal Cortex Transcriptome Analysis of Mice Exposed to Electronic Cigarettes During Early Life Stages.PMC4847079P30ES000260-50P30 ES000260Zelikoff JTLauterstein DECorbett KGordon TKlein CBAkgol Oksuz BTijerina PBShen SSfalseFrontal Cortex Transcriptome Analysis of Mice Exposed to Electronic Cigarettes During Early Life Stages.Electronic cigarettes (e-cigarettes), battery-powered devices containing nicotine, glycerin, propylene glycol, flavorings, and other substances, are increasing in popularity. They pose a potential threat to the developing brain, as nicotine is a known neurotoxicant. We hypothesized that exposure to e-cigarettes during early life stages induce changes in central nervous system (CNS) transcriptome associated with adverse neurobiological outcomes and long-term disease states. To test the hypothesis, pregnant C57BL/6 mice were exposed daily (via whole body inhalation) throughout gestation (3 h/day; 5 days/week) to aerosols produced from e-cigarettes either with nicotine (13-16 mg/mL) or without nicotine; following birth, pups and dams were exposed together to e-cigarette aerosols throughout la2016-01-01T00:00:00Z2016 Apr2025-04-26T10:52:13.424Z2019-03-26T22:35:20ZS-EPMC48470792707787310.3390/ijerph13040417