{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(5)"],"submitter":["Stenvinkel P"],"pubmed_abstract":["High body mass index (BMI) is paradoxically associated with better outcome in hemodialysis (HD) patients. Persistent inflammation commonly features in clinical conditions where the obesity paradox is described. We examined the relationship between BMI and mortality in HD patients, accounting for inflammation, in a historic cohort study of 5904 incident HD patients enrolled in 2007-2009 (312 facilities; 15 European countries) with ≥3 months of follow-up. Patients were classified by presence (n=3231) or absence (n=2673) of inflammation (C-reactive protein ≥10 mg/l and/or albumin ≤35 g/l). Patients were divided into quintiles by BMI (Q1-Q5: <21.5, 21.5-24.0, >24.0-26.4, >26.4-29.8, and >29.8 kg/m(2), respectively). Noninflamed patients in BMI Q5 formed the reference group. During a median fol"],"journal":["Journal of the American Society of Nephrology : JASN"],"pagination":["1479-86"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4849822"],"repository":["biostudies-literature"],"pubmed_title":["Inflammation Modifies the Paradoxical Association between Body Mass Index and Mortality in Hemodialysis Patients."],"pmcid":["PMC4849822"],"pubmed_authors":["Eckardt KU","Kronenberg F","Stenvinkel P","Tunks J","Addison J","Drueke TB","Froissart M","Anker SD","Schernthaner G","Gillespie IA","Floege J","ARO Steering Committee","Marcelli D"],"additional_accession":[]},"is_claimable":false,"name":"Inflammation Modifies the Paradoxical Association between Body Mass Index and Mortality in Hemodialysis Patients.","description":"High body mass index (BMI) is paradoxically associated with better outcome in hemodialysis (HD) patients. Persistent inflammation commonly features in clinical conditions where the obesity paradox is described. We examined the relationship between BMI and mortality in HD patients, accounting for inflammation, in a historic cohort study of 5904 incident HD patients enrolled in 2007-2009 (312 facilities; 15 European countries) with ≥3 months of follow-up. Patients were classified by presence (n=3231) or absence (n=2673) of inflammation (C-reactive protein ≥10 mg/l and/or albumin ≤35 g/l). Patients were divided into quintiles by BMI (Q1-Q5: <21.5, 21.5-24.0, >24.0-26.4, >26.4-29.8, and >29.8 kg/m(2), respectively). Noninflamed patients in BMI Q5 formed the reference group. During a median fol","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2025-04-04T07:30:36.255Z","creation":"2019-03-27T02:12:40Z"},"accession":"S-EPMC4849822","cross_references":{"pubmed":["26567245"],"doi":["10.1681/asn.2015030252","10.1681/ASN.2015030252"]}}