{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rudant J"],"funding":["NIEHS NIH HHS","NCI NIH HHS"],"pagination":["549-62"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4850899"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["181(8)"],"pubmed_abstract":["The associations between childhood acute lymphoblastic leukemia (ALL) and several proxies of early stimulation of the immune system, that is, day-care center attendance, birth order, maternally reported common infections in infancy, and breastfeeding, were investigated by using data from 11 case-control studies participating in the Childhood Leukemia International Consortium (enrollment period: 1980-2010). The sample included 7,399 ALL cases and 11,181 controls aged 2-14 years. The data were collected by questionnaires administered to the parents. Pooled odds ratios and 95% confidence intervals were estimated by unconditional logistic regression adjusted for age, sex, study, maternal education, and maternal age. Day-care center attendance in the first year of life was associated with a reduced risk of ALL (odds ratio = 0.77, 95% confidence interval: 0.71, 0.84), with a marked inverse trend with earlier age at start (P < 0.0001). An inverse association was also observed with breastfeeding duration of 6 months or more (odds ratio = 0.86, 95% confidence interval: 0.79, 0.94). No significant relationship with a history of common infections in infancy was observed even though the odds ratio was less than 1 for more than 3 infections. The findings of this large pooled analysis reinforce the hypothesis that day-care center attendance in infancy and prolonged breastfeeding are associated with a decreased risk of ALL."],"journal":["American journal of epidemiology"],"pubmed_title":["Childhood acute lymphoblastic leukemia and indicators of early immune stimulation: a Childhood Leukemia International Consortium study."],"pmcid":["PMC4850899"],"funding_grant_id":["R03CA132172","R13 ES021145-01","R01 ES09137","R01CA049450","1R13 ES024632-01","P42-ES04705","R01CA048051","1R13 CA174342-01","P01 ES018172"],"pubmed_authors":["Lightfoot T","Miller M","Rondelli R","Clavel J","Magnani C","Orsi L","Dockerty JD","Ashton LJ","Dessypris N","Roman E","Infante-Rivard C","Rudant J","Simpson J","Metayer C","Stiakaki E","Urayama KY","Petridou E","Spector LG","Milne E","Kang AY"],"additional_accession":[]},"is_claimable":false,"name":"Childhood acute lymphoblastic leukemia and indicators of early immune stimulation: a Childhood Leukemia International Consortium study.","description":"The associations between childhood acute lymphoblastic leukemia (ALL) and several proxies of early stimulation of the immune system, that is, day-care center attendance, birth order, maternally reported common infections in infancy, and breastfeeding, were investigated by using data from 11 case-control studies participating in the Childhood Leukemia International Consortium (enrollment period: 1980-2010). The sample included 7,399 ALL cases and 11,181 controls aged 2-14 years. The data were collected by questionnaires administered to the parents. Pooled odds ratios and 95% confidence intervals were estimated by unconditional logistic regression adjusted for age, sex, study, maternal education, and maternal age. Day-care center attendance in the first year of life was associated with a reduced risk of ALL (odds ratio = 0.77, 95% confidence interval: 0.71, 0.84), with a marked inverse trend with earlier age at start (P < 0.0001). An inverse association was also observed with breastfeeding duration of 6 months or more (odds ratio = 0.86, 95% confidence interval: 0.79, 0.94). No significant relationship with a history of common infections in infancy was observed even though the odds ratio was less than 1 for more than 3 infections. The findings of this large pooled analysis reinforce the hypothesis that day-care center attendance in infancy and prolonged breastfeeding are associated with a decreased risk of ALL.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Apr","modification":"2026-05-29T18:19:28.548Z","creation":"2019-03-27T02:12:44Z"},"accession":"S-EPMC4850899","cross_references":{"pubmed":["25731888"],"doi":["10.1093/aje/kwu298"]}}