{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Foks AC"],"funding":["NIAID NIH HHS","NHLBI NIH HHS"],"pagination":["456-65"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4853762"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["36(3)"],"pubmed_abstract":["Objective
T cell immunoglobulin and mucin domain (Tim) proteins are expressed by numerous immune cells, recognize phosphatidylserine on apoptotic cells, and function as costimulators or coinhibitors. Tim-1 is expressed by activated T cells but is also found on dendritic cells and B cells. Tim-4, present on macrophages and dendritic cells, plays a critical role in apoptotic cell clearance, regulates the number of phosphatidylserine-expressing activated T cells, and is genetically associated with low low-density lipoprotein and triglyceride levels. Because these functions of Tim-1 and Tim-4 could affect atherosclerosis, their modulation has potential therapeutic value in cardiovascular disease.Approach and results
ldlr(-/-) mice were fed a high-fat diet for 4 weeks while bein"],"journal":["Arteriosclerosis, thrombosis, and vascular biology"],"pubmed_title":["Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice."],"pmcid":["PMC4853762"],"funding_grant_id":["HL087282","P50 HL056985","R01 HL087282","R01AI089955","R01 HL121363","P01AI054456","R01 AI089955","P01 AI054456"],"pubmed_authors":["Kuperwaser F","Gonen A","Jarolim P","DeKruyff RH","Freeman GJ","Witztum JL","Alberts-Grill N","Foks AC","Lederer J","Lichtman AH","Engelbertsen D"],"additional_accession":[]},"is_claimable":false,"name":"Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice.","description":"Objective
T cell immunoglobulin and mucin domain (Tim) proteins are expressed by numerous immune cells, recognize phosphatidylserine on apoptotic cells, and function as costimulators or coinhibitors. Tim-1 is expressed by activated T cells but is also found on dendritic cells and B cells. Tim-4, present on macrophages and dendritic cells, plays a critical role in apoptotic cell clearance, regulates the number of phosphatidylserine-expressing activated T cells, and is genetically associated with low low-density lipoprotein and triglyceride levels. Because these functions of Tim-1 and Tim-4 could affect atherosclerosis, their modulation has potential therapeutic value in cardiovascular disease.Approach and results
ldlr(-/-) mice were fed a high-fat diet for 4 weeks while bein","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Mar","modification":"2026-05-05T08:28:38.595Z","creation":"2019-03-27T02:12:53Z"},"accession":"S-EPMC4853762","cross_references":{"pubmed":["26821944"],"doi":["10.1161/ATVBAHA.115.306860","10.1161/atvbaha.115.306860"]}}