{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maldonado A"],"funding":["NIGMS NIH HHS"],"pagination":["e0154208"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4854401"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(5)"],"pubmed_abstract":["Some species of butterflyfish have had preyed upon corals for millions of years, yet the mechanism of butterflyfish specialized coral feeding strategy remains poorly understood. Certain butterflyfish have the ability to feed on allelochemically rich soft corals, e.g. Sinularia maxima. Cytochrome P450 (CYP) is the predominant enzyme system responsible for the detoxification of dietary allelochemicals. CYP2-like and CYP3A-like content have been associated with butterflyfish that preferentially consumes allelochemically rich soft corals. To investigate the role of butterflyfish CYP2 and CYP3A enzymes in dietary preference, we conducted oral feeding experiments using homogenates of S. maxima and a toxin isolated from the coral in four species of butterflyfish with different feeding strategies."],"journal":["PloS one"],"pubmed_title":["Biochemical Mechanisms for Geographical Adaptations to Novel Toxin Exposures in Butterflyfish."],"pmcid":["PMC4854401"],"funding_grant_id":["P20 GM104932"],"pubmed_authors":["Maldonado A","Goldstone JV","Rimoldi JM","Ostrander GK","Schlenk D","Lavado R","Ankisetty S","Watanabe K","Slattery M","Hoh E","Gadepalli RS","Knuston S"],"additional_accession":[]},"is_claimable":false,"name":"Biochemical Mechanisms for Geographical Adaptations to Novel Toxin Exposures in Butterflyfish.","description":"Some species of butterflyfish have had preyed upon corals for millions of years, yet the mechanism of butterflyfish specialized coral feeding strategy remains poorly understood. Certain butterflyfish have the ability to feed on allelochemically rich soft corals, e.g. Sinularia maxima. Cytochrome P450 (CYP) is the predominant enzyme system responsible for the detoxification of dietary allelochemicals. CYP2-like and CYP3A-like content have been associated with butterflyfish that preferentially consumes allelochemically rich soft corals. To investigate the role of butterflyfish CYP2 and CYP3A enzymes in dietary preference, we conducted oral feeding experiments using homogenates of S. maxima and a toxin isolated from the coral in four species of butterflyfish with different feeding strategies.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2026-05-30T13:01:18.893Z","creation":"2019-03-26T22:54:47Z"},"accession":"S-EPMC4854401","cross_references":{"pubmed":["27136924"],"doi":["10.1371/journal.pone.0154208"]}}