{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Feng Z"],"funding":["NCI NIH HHS","National Institutes of Health"],"pagination":["6332-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4855835"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(37)"],"pubmed_abstract":["Here we reported the first case in which enhancing self-assembling ability boosts anti-cancer efficacy through a simple and minimal modification of the C-terminus of a d-tripeptide. By only a 2% change of the molecular weight, this facile approach increases the inhibitory activity by over an order of magnitude (IC50 from 431 to 23 μM) towards an osteosarcoma cell line."],"journal":["Chemical communications (Cambridge, England)"],"pubmed_title":["Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells."],"pmcid":["PMC4855835"],"funding_grant_id":["CA142746","R01 CA142746"],"pubmed_authors":["Li J","Feng Z","Xu B","Du X","Wang H","Shi J"],"additional_accession":[]},"is_claimable":false,"name":"Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells.","description":"Here we reported the first case in which enhancing self-assembling ability boosts anti-cancer efficacy through a simple and minimal modification of the C-terminus of a d-tripeptide. By only a 2% change of the molecular weight, this facile approach increases the inhibitory activity by over an order of magnitude (IC50 from 431 to 23 μM) towards an osteosarcoma cell line.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2025-04-04T02:43:01.859Z","creation":"2019-03-27T02:12:59Z"},"accession":"S-EPMC4855835","cross_references":{"pubmed":["27087169"],"doi":["10.1039/c6cc02282k"]}}