biostudies-literatureFeng ZNCI NIH HHSNational Institutes of Health6332-5https://www.ebi.ac.uk/biostudies/studies/S-EPMC4855835biostudies-literatureUnknown52(37)Here we reported the first case in which enhancing self-assembling ability boosts anti-cancer efficacy through a simple and minimal modification of the C-terminus of a d-tripeptide. By only a 2% change of the molecular weight, this facile approach increases the inhibitory activity by over an order of magnitude (IC50 from 431 to 23 μM) towards an osteosarcoma cell line.Chemical communications (Cambridge, England)Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells.PMC4855835CA142746R01 CA142746Li JFeng ZXu BDu XWang HShi JfalseMinimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells.Here we reported the first case in which enhancing self-assembling ability boosts anti-cancer efficacy through a simple and minimal modification of the C-terminus of a d-tripeptide. By only a 2% change of the molecular weight, this facile approach increases the inhibitory activity by over an order of magnitude (IC50 from 431 to 23 μM) towards an osteosarcoma cell line.2016-01-01T00:00:00Z2016 May2025-04-04T02:43:01.859Z2019-03-27T02:12:59ZS-EPMC48558352708716910.1039/c6cc02282k