{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chiappini C"],"funding":["Rosetrees Trust","Wellcome Trust Senior Investigator","European Research Council","FCT","EPSRC","Wellcome Trust","Engineering and Physical Sciences Research Council"],"pagination":["5147-52"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4858817"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(35)"],"pubmed_abstract":["Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide-based Cathepsin B cleavable sensor over a large array of nano-needles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tumor margin area of esophageal adenocarcinoma."],"journal":["Advanced materials (Deerfield Beach, Fla.)"],"pubmed_title":["Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles."],"pmcid":["PMC4858817"],"funding_grant_id":["088844","098411/Z/12/Z","098411","M300-CD1","EP/K020641/1","98411","M300-F1-CD3","SFRH/BD/80544/2011","616417"],"pubmed_authors":["Abbassi-Ghadi N","Chiappini C","Chow LW","Hanna GB","Campagnolo P","Almeida CS","Stevens MM"],"additional_accession":[]},"is_claimable":false,"name":"Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles.","description":"Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide-based Cathepsin B cleavable sensor over a large array of nano-needles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tumor margin area of esophageal adenocarcinoma.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2024-11-20T03:44:52.012Z","creation":"2019-03-27T02:13:11Z"},"accession":"S-EPMC4858817","cross_references":{"pubmed":["26197973"],"doi":["10.1002/adma.201501304"]}}