biostudies-literatureChiappini CRosetrees TrustWellcome Trust Senior InvestigatorEuropean Research CouncilFCTEPSRCWellcome TrustEngineering and Physical Sciences Research Council5147-52https://www.ebi.ac.uk/biostudies/studies/S-EPMC4858817biostudies-literatureUnknown27(35)Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide-based Cathepsin B cleavable sensor over a large array of nano-needles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tumor margin area of esophageal adenocarcinoma.Advanced materials (Deerfield Beach, Fla.)Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles.PMC4858817088844098411/Z/12/Z098411M300-CD1EP/K020641/198411M300-F1-CD3SFRH/BD/80544/2011616417Abbassi-Ghadi NChiappini CChow LWHanna GBCampagnolo PAlmeida CSStevens MMfalseMapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles.Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide-based Cathepsin B cleavable sensor over a large array of nano-needles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tumor margin area of esophageal adenocarcinoma.2015-01-01T00:00:00Z2015 Sep2024-11-20T03:44:52.012Z2019-03-27T02:13:11ZS-EPMC48588172619797310.1002/adma.201501304