{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Oda-Ishii I"],"funding":["Japan Science and Technology Agency","Japan Society for the Promotion of Science"],"pagination":["e1006045"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4859511"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(5)"],"pubmed_abstract":["Maternal factors initiate the zygotic developmental program in animal embryos. In embryos of the chordate, Ciona intestinalis, three maternal factors-Gata.a, β-catenin, and Zic-r.a-are required to establish three domains of gene expression at the 16-cell stage; the animal hemisphere, vegetal hemisphere, and posterior vegetal domains. Here, we show how the maternal factors establish these domains. First, only β-catenin and its effector transcription factor, Tcf7, are required to establish the vegetal hemisphere domain. Second, genes specifically expressed in the posterior vegetal domain have additional repressive cis-elements that antagonize the activity of β-catenin/Tcf7. This antagonizing activity is suppressed by Zic-r.a, which is specifically localized in the posterior vegetal domain an"],"journal":["PLoS genetics"],"pubmed_title":["A Maternal System Initiating the Zygotic Developmental Program through Combinatorial Repression in the Ascidian Embryo."],"pmcid":["PMC4859511"],"funding_grant_id":["25118510","CREST","15k14447","25–40065"],"pubmed_authors":["Kubo A","Oda-Ishii I","Kari W","Suzuki N","Satou Y","Rothbacher U"],"additional_accession":[]},"is_claimable":false,"name":"A Maternal System Initiating the Zygotic Developmental Program through Combinatorial Repression in the Ascidian Embryo.","description":"Maternal factors initiate the zygotic developmental program in animal embryos. In embryos of the chordate, Ciona intestinalis, three maternal factors-Gata.a, β-catenin, and Zic-r.a-are required to establish three domains of gene expression at the 16-cell stage; the animal hemisphere, vegetal hemisphere, and posterior vegetal domains. Here, we show how the maternal factors establish these domains. First, only β-catenin and its effector transcription factor, Tcf7, are required to establish the vegetal hemisphere domain. Second, genes specifically expressed in the posterior vegetal domain have additional repressive cis-elements that antagonize the activity of β-catenin/Tcf7. This antagonizing activity is suppressed by Zic-r.a, which is specifically localized in the posterior vegetal domain an","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2026-05-30T10:49:11.136Z","creation":"2026-04-08T07:05:33.663Z"},"accession":"S-EPMC4859511","cross_references":{"pubmed":["27152625"],"doi":["10.1371/journal.pgen.1006045"]}}