{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Borowski KS"],"funding":["NICHD NIH HHS","NCRR NIH HHS"],"pagination":["1126-32"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4860012"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(12)"],"pubmed_abstract":["<h4>Objective</h4>The aim of the study is to evaluate the association of steroid metabolism and respiratory gene polymorphisms in neonates exposed to antenatal corticosteroids (ACS) with respiratory outcomes, small for gestational age (SGA), and response to repeat ACS.<h4>Study design</h4>This candidate gene study is a secondary analysis of women enrolled in a randomized controlled trial of single versus weekly courses of ACS. Nineteen single nucleotide polymorphisms (SNPs) in 13 steroid metabolism and respiratory function genes were evaluated. DNA was extracted from placenta or fetal cord serum and analyzed with TaqMan genotyping. Each SNP was evaluated for association via logistic regression with respiratory distress syndrome (RDS), continuous positive airway pressure (CPAP)/ventilator u"],"journal":["American journal of perinatology"],"pubmed_title":["Neonatal Genetic Variation in Steroid Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids."],"pmcid":["PMC4860012"],"funding_grant_id":["U10 HD040485","HD40485","U10 HD027905","U10 HD040560","U24 HD036801","U10 HD034122","HD40560","HD34208","U10 HD034208","U10 HD027860","HD27915","HD21410","U10 HD027869","HD27917","HD21414","HD40512","U10 HD027915","U10 HD027917","M01-RR-000080","HD34116","U10 HD034116","HD27860","HD27861","UG1 HD040544","UG1 HD040500","UG1 HD040545","U10 HD021410","HD27869","U10 HD040512","HD40500","HD40544","HD40545","UG1 HD027869","K23 HD061910","HD36801","U01 HD036801","U10 HD036801","UG1 HD034116","UG1 HD040512","U10 HD040500","U10 HD040544","U10 HD040545","UG1 HD027915","M01 RR000080","HD34136","U10 HD034136","P2C HD050924","UG1 HD034208","UG1 HD040485","UG1 HD040560"],"pubmed_authors":["O'Sullivan MJ","Catalano P","Sibai B","Elder N","Howell K","Murray J","Mesa P","Lain K","Dudley D","Ramin SM","Meadows S","Gilstrap L","Borowski KS","Thorp JM","Sorokin Y","Fay-Randall L","Kamon T","Berghella V","Millinder A","Pagliaro S","Milluzzi C","Day MC","Pemberton V","Mabie B","Moawad A","Northen A","Jones P","Galbis-Reig F","Shubert P","Meis P","Leuchtenburg L","Pollock M","Bailey K","Tillinghast J","Mele L","Bousleiman S","Spong C","Mallett G","Harper M","Rouse DJ","Moise K","Varner M","Guzman A","Malone F","Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network","Sciscione A","Talucci M","Swain M","Peaceman AM","Thom E","Alexander B","Norman G","Landon M","Moorefield C","Caritis SN","Cotroneo M","Iams JD","Johnson F","Crowley A","Doyle F","Weightman D","Wapner RJ","Clark EA","Dombrowski M","Santori C","Dorman K","Carpenter MW","Driscoll D","Martin D","Mercer BM","Anderson K","Lai Y","Fuller M","Allard D","How H","McNellis D","Leveno KJ","Sudz C","Ramsey R","Miodovnik M","Girdler W"],"additional_accession":[]},"is_claimable":false,"name":"Neonatal Genetic Variation in Steroid Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids.","description":"<h4>Objective</h4>The aim of the study is to evaluate the association of steroid metabolism and respiratory gene polymorphisms in neonates exposed to antenatal corticosteroids (ACS) with respiratory outcomes, small for gestational age (SGA), and response to repeat ACS.<h4>Study design</h4>This candidate gene study is a secondary analysis of women enrolled in a randomized controlled trial of single versus weekly courses of ACS. Nineteen single nucleotide polymorphisms (SNPs) in 13 steroid metabolism and respiratory function genes were evaluated. DNA was extracted from placenta or fetal cord serum and analyzed with TaqMan genotyping. Each SNP was evaluated for association via logistic regression with respiratory distress syndrome (RDS), continuous positive airway pressure (CPAP)/ventilator u","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Oct","modification":"2026-05-30T10:52:26.649Z","creation":"2019-03-27T02:13:14Z"},"accession":"S-EPMC4860012","cross_references":{"pubmed":["26445141"],"doi":["10.1055/s-0035-1549217"]}}