{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Colomb J"],"funding":["Swiss National Science Foundation","Deutsche Forschungsgemeinschaft","NIH HHS"],"pagination":["e1971"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4860329"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4"],"pubmed_abstract":["Tethering a fly for stationary flight allows for exquisite control of its sensory input, such as visual or olfactory stimuli or a punishing infrared laser beam. A torque meter measures the turning attempts of the tethered fly around its vertical body axis. By punishing, say, left turning attempts (in a homogeneous environment), one can train a fly to restrict its behaviour to right turning attempts. It was recently discovered that this form of operant conditioning (called operant self-learning), may constitute a form of motor learning in Drosophila. Previous work had shown that Protein Kinase C (PKC) and the transcription factor dFoxP were specifically involved in self-learning, but not in other forms of learning. These molecules are specifically involved in various forms of motor learning"],"journal":["PeerJ"],"pubmed_title":["PKC in motorneurons underlies self-learning, a form of motor learning in Drosophila."],"pmcid":["PMC4860329"],"funding_grant_id":["BR 1892/7-1","DFG:BR 1892/6-1","SNF: PAOOP3_124141","124141","P40 OD018537"],"pubmed_authors":["Brembs B","Colomb J"],"additional_accession":[]},"is_claimable":false,"name":"PKC in motorneurons underlies self-learning, a form of motor learning in Drosophila.","description":"Tethering a fly for stationary flight allows for exquisite control of its sensory input, such as visual or olfactory stimuli or a punishing infrared laser beam. A torque meter measures the turning attempts of the tethered fly around its vertical body axis. By punishing, say, left turning attempts (in a homogeneous environment), one can train a fly to restrict its behaviour to right turning attempts. It was recently discovered that this form of operant conditioning (called operant self-learning), may constitute a form of motor learning in Drosophila. Previous work had shown that Protein Kinase C (PKC) and the transcription factor dFoxP were specifically involved in self-learning, but not in other forms of learning. These molecules are specifically involved in various forms of motor learning","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-04-22T04:15:09.541Z","creation":"2019-03-27T02:13:15Z"},"accession":"S-EPMC4860329","cross_references":{"pubmed":["27168980"],"doi":["10.7717/peerj.1971"]}}