{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cai Y"],"funding":["National Institute of Environmental Health Sciences","European Commission Directorate-General for Research and Innovation","NCRR NIH HHS","NIEHS NIH HHS","Ministero dell'Istruzione, dell'Università e della Ricerca","National Cancer Institute","NCI NIH HHS"],"pagination":["4181-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4862310"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["54(27)"],"pubmed_abstract":["In nucleosomes, the access of DNA lesions to nucleotide excision repair is hindered by histone proteins. However, evidence that the nature of the DNA lesions may play a role in facilitating access is emerging, but these phenomena are not well-understood. We have used molecular dynamics simulations to elucidate the structural, dynamic, and energetic properties of the R and S 5'-8-cyclo-2'-dG and the (+)-cis-anti-B[a]P-dG lesions in a nucleosome. Our results show that the (+)-cis-anti-B[a]P-dG adduct is more dynamic and more destabilizing than the smaller and more constrained 5',8-cyclo-2'-dG lesions, suggesting more facile access to the more bulky (+)-cis-anti-B[a]P-dG lesion."],"journal":["Biochemistry"],"pubmed_title":["Differences in the Access of Lesions to the Nucleotide Excision Repair Machinery in Nucleosomes."],"pmcid":["PMC4862310"],"funding_grant_id":["R01 ES 011589","CA28038","R01 CA168469","R01 CA028038","PRIN-2009K3RH7N_002","R01 CA075449","298555","R01 ES011589","C06 RR016572"],"pubmed_authors":["Chatgilialoglu C","Kropachev K","Shafirovich V","Geacintov NE","Cai Y","Terzidis MA","Masi A","Broyde S"],"additional_accession":[]},"is_claimable":false,"name":"Differences in the Access of Lesions to the Nucleotide Excision Repair Machinery in Nucleosomes.","description":"In nucleosomes, the access of DNA lesions to nucleotide excision repair is hindered by histone proteins. However, evidence that the nature of the DNA lesions may play a role in facilitating access is emerging, but these phenomena are not well-understood. We have used molecular dynamics simulations to elucidate the structural, dynamic, and energetic properties of the R and S 5'-8-cyclo-2'-dG and the (+)-cis-anti-B[a]P-dG lesions in a nucleosome. Our results show that the (+)-cis-anti-B[a]P-dG adduct is more dynamic and more destabilizing than the smaller and more constrained 5',8-cyclo-2'-dG lesions, suggesting more facile access to the more bulky (+)-cis-anti-B[a]P-dG lesion.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul","modification":"2024-11-20T03:19:22.868Z","creation":"2019-03-27T02:13:26Z"},"accession":"S-EPMC4862310","cross_references":{"pubmed":["26091016"],"doi":["10.1021/acs.biochem.5b00564"]}}