{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tan XW"],"funding":["Melbourne-Sarawak Research Collaboration Scheme"],"pagination":["6943053"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4863109"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2016"],"pubmed_abstract":["This study was aimed at preliminarily assessing the cytoprotective and antioxidative effects of rice bran extracts (RBEs) from a Sarawak local rice variety (local name: \"BJLN\") and a commercial rice variety, \"MR219,\" on oxidative stress in rat H9c2(2-1) cardiomyocytes. The cardiomyocytes were incubated with different concentrations of RBE and hydrogen peroxide (H2O2), respectively, to identify their respective IC50 values and safe dose ranges. Two nonlethal and close-to-IC50 doses of RBE were selected to evaluate their respective effects on H2O2 induced oxidative stress in cardiomyocytes. Both RBEs showed dose-dependent cytotoxicity effects on cardiomyocytes. H2O2 induction of cardiomyocytes pretreated with RBE further revealed the dose-dependent cytoprotective and antioxidative effects of"],"journal":["Oxidative medicine and cellular longevity"],"pubmed_title":["Cytoprotective and Cytotoxic Effects of Rice Bran Extracts in Rat H9c2(2-1) Cardiomyocytes."],"pmcid":["PMC4863109"],"funding_grant_id":["MSRCS 2013","StraRG 2-5607"],"pubmed_authors":["Matsuura E","Shen LH","Bhave M","Hwang SS","Fong AY","Tan XW","Kobayashi K"],"additional_accession":[]},"is_claimable":false,"name":"Cytoprotective and Cytotoxic Effects of Rice Bran Extracts in Rat H9c2(2-1) Cardiomyocytes.","description":"This study was aimed at preliminarily assessing the cytoprotective and antioxidative effects of rice bran extracts (RBEs) from a Sarawak local rice variety (local name: \"BJLN\") and a commercial rice variety, \"MR219,\" on oxidative stress in rat H9c2(2-1) cardiomyocytes. The cardiomyocytes were incubated with different concentrations of RBE and hydrogen peroxide (H2O2), respectively, to identify their respective IC50 values and safe dose ranges. Two nonlethal and close-to-IC50 doses of RBE were selected to evaluate their respective effects on H2O2 induced oxidative stress in cardiomyocytes. Both RBEs showed dose-dependent cytotoxicity effects on cardiomyocytes. H2O2 induction of cardiomyocytes pretreated with RBE further revealed the dose-dependent cytoprotective and antioxidative effects of","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-04-22T06:19:25.452Z","creation":"2019-03-27T02:13:27Z"},"accession":"S-EPMC4863109","cross_references":{"pubmed":["27239253"],"doi":["10.1155/2016/6943053"]}}