{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bodea CA"],"funding":["NIDDK NIH HHS","Medical Research Council","NIMH NIH HHS","Chief Scientist Office","National Institute for Health Research (NIHR)","Parkinson's UK"],"pagination":["857-868"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4864319"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["98(5)"],"pubmed_abstract":["One goal of human genetics is to understand the genetic basis of disease, a challenge for diseases of complex inheritance because risk alleles are few relative to the vast set of benign variants. Risk variants are often sought by association studies in which allele frequencies in case subjects are contrasted with those from population-based samples used as control subjects. In an ideal world we would know population-level allele frequencies, releasing researchers to focus on case subjects. We argue this ideal is possible, at least theoretically, and we outline a path to achieving it in reality. If such a resource were to exist, it would yield ample savings and would facilitate the effective use of data repositories by removing administrative and technical barriers. We call this concept the"],"journal":["American journal of human genetics"],"pubmed_title":["A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies."],"pmcid":["PMC4864319"],"funding_grant_id":["NF-SI-0611-10219","U01 DK062420","G0800759","MR/L501554/1","CZB/4/540","R01 MH057881","G0800675","MC_G0901330","ETM/75","MC_UU_12013/4","R37 MH057881","R01 MH101244","1202121","G0600329","G-1107","J-0804","ETM/137"],"pubmed_authors":["Stevens HE","Milla M","Nimmo ER","Wain LV","McGuffin P","Wood NW","Parnell K","Mathew CG","Groves CJ","Ferrier N","Ferguson J","Bampton PA","Kirov G","Su Z","Widaa S","Van Gossum A","Goyette P","Walker M","Trembath RC","Spanova K","Yau C","Cardin N","Blackwell JM","Gordon-Smith K","Katz S","Jain M","Russell E","International IBD Genetics Consortium","Binion DG","Forbes A","Caulfield MJ","Croft A","Lawrance IC","McArdle WL","Zeggini E","Jolley JD","Neale BM","Mahy G","Jewell DP","Daly MJ","D'Inca R","Langford CF","Howard E","Munroe PB","Seal S","Young AH","Auton A","Attwood A","Elliot A","Parkes M","Massey D","Donnelly P","Ublick K","Coffey AJ","Isaacs JD","Howard P","Dudakia D","Viswanathan AC","Brown MJ","Stratton MR","Vermeire S","Hinks A","Hall A","Bhaskar S","Pernet D","Woodburn M","Zhao H","Liddle J","Chamaillard M","Hocking L","Brown MA","Hugot JP","Vatn MH","Hines S","Franklyn JA","Connell JMC","Green E","St Clair D","Sanderson JD","Taylor KM","Hanigan K","Scott CE","Rayner NW","Hill AVS","Cohen A","Giannoulatou E","Gray E","Grozeva D","Onipinla A","Lathrop GM","Mentzer A","Pearson R","Karban A","Ng SM","Jones LA","Prescott NJ","Travers ME","Warren-Perry M","Roberts R","Gough SCL","Georges M","Datta LW","Lahaie RG","Swoger JM","Blaszczyk K","Evans DM","Palin K","Worthington J","Prokopenko I","Bellenguez C","McCann OT","Gearry R","Lewis K","Jobin G","Flynn E","Gwilliam R","Edkins S","Hunt S","Evans G","Gilbert P","Roeder K","Spencer CCA","Nelson L","Steinhart AH","Bramon E","Ng SME","Eccles D","Myers S","Owen MJ","Samani NJ","Stone MA","Laukens D","Andrews JM","Wallace C","Sharma Y","Barnes C","Regueiro MD","Haritunians T","Kwiatkowski DP","Krishnaprasad K","Colombel JF","Smyth DJ","Blackburn H","Bumpstead SJ","Oikonomou I","Walker NM","Wordsworth BP","Barton A","Van Limbergen J","Barrie AM","Johnson T","Somaskantharajah E","Ripke S","Fultz J","Peeters H","Schuilenburg H","Tsagarelis C","Peyrin-Biroulet L","Cho JH","Scott R","Phillips A","Mansfield J","Perry JRB","Morris AP","Bitton A","Symmons DPM","Montgomery GW","Hitman GA","Hellenthal G","Dronov S","Eyre S","Hebaishi H","Baidoo L","Ning K","Morgan AE","Zhang W","Ball SG","Maisuria-Armer M","Roberts RL","Massey DCO","Burren OS","Dutridge D","Robertson N","Strange A","Marchini JL","McCarthy MI","Cooper JD","Schumm LP","Ring SM","Ricketts M","Vukcevic D","Bredin F","Lees C","Duncanson A","Zhang H","Emery P","Sawcer SJ","Torkvist L","Plomin R","Palotie A","Satsangi J","Band G","Martin P","Hughes D","Frayling TM","McGovern DP","Zhang C","Duerr RH","Renwick A","Levine A","Ebbs B","Turnbull C","Rafelt S","Bennett AJ","Potter SC","Beck K","Bernard EJ","Corvin A","Hall AS","Reid DM","Hattersley AT","Pare P","Hurles ME","Halfvarson J","Theatre E","Newman W","Tobin MD","Forty L","Compston A","O'Donovan MC","Lee J","Rahier JF","Clee CM","Whittaker P","Henderson P","Deloukas P","Edwards C","Cleynen I","Kennedy NA","Aumais G","Howson JMM","Ouwehand WH","Pirinen M","Burton PR","Thomson W","Dunham A","Hassanali N","Franchimont D","Brand OJ","Bruce IN","Farmer A","Lemann M","Bodea CA","Byrnes J","Mowat C","Weedon MN","Balmforth AJ","Robson S","Ruggiero E","Gibbs P","Lee KL","Simms LA","Amininijad L","Khan MA","Simmonds MJ","Rioux JD","Palmer CNA","Bowes J","Braund PS","Proctor DD","Stephens J","Ahmad T","Arbury H","Sambrook JG","Barclay M","Lindgren CM","Rautanen A","Hammond N","Croitoru K","Holmes C","Seibold F","Plagnol V","Barroso I","Silverberg MS","Webster J","Cottone M","Deslandres C","Breen G","Maller J","Barrett JC","Markus HS","Freeman C","Casas JP","Waller M","Florin TH","Rahman N","McLay KE","Dewit O","Jones IR","Weston P","Farrall M","Radford-Smith G","Gillman M","Todd JA","Devlin B","Freathy RM","Stronati L","Quail MA","Harrison P","Hardy M","Mimmack ML","Conrad DF","Ovington NR","Ravindrarajah R","Lango-Allen H","Watkins NA","Dominiczak AF","Caesar S","McVean G","Pembrey M","Greenberg GR","Burton J","Aerts J","Bull J","Spears D","Jankowski J","Shaw-Hawkins S","Stempak JM","Wilson AG","Thompson JR","Strachan DP","Downes K","Schwartz M","Shields BM","Craddock N","Rutgeerts P","Steer S","Brant SR","Drummond HE","Stirrups K","Jayakumar A"],"additional_accession":[]},"is_claimable":false,"name":"A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.","description":"One goal of human genetics is to understand the genetic basis of disease, a challenge for diseases of complex inheritance because risk alleles are few relative to the vast set of benign variants. Risk variants are often sought by association studies in which allele frequencies in case subjects are contrasted with those from population-based samples used as control subjects. In an ideal world we would know population-level allele frequencies, releasing researchers to focus on case subjects. We argue this ideal is possible, at least theoretically, and we outline a path to achieving it in reality. If such a resource were to exist, it would yield ample savings and would facilitate the effective use of data repositories by removing administrative and technical barriers. We call this concept the","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2026-05-30T02:22:26.199Z","creation":"2019-03-27T02:13:31Z"},"accession":"S-EPMC4864319","cross_references":{"pubmed":["27087321"],"doi":["10.1016/j.ajhg.2016.02.025"]}}