biostudies-literatureCarter KWLundbeck Foundation408-416https://www.ebi.ac.uk/biostudies/studies/S-EPMC4864874biostudies-literatureUnknown45(2)<h4>Background</h4>Research studies exploring the determinants of disease require sufficient statistical power to detect meaningful effects. Sample size is often increased through centralized pooling of disparately located datasets, though ethical, privacy and data ownership issues can often hamper this process. Methods that facilitate the sharing of research data that are sympathetic with these issues and which allow flexible and detailed statistical analyses are therefore in critical need. We have created a software platform for the Virtual Pooling and Analysis of Research data (ViPAR), which employs free and open source methods to provide researchers with a web-based platform to analyse datasets housed in disparate locations.<h4>Methods</h4>Database federation permits controlled access International journal of epidemiologyViPAR: a software platform for the Virtual Pooling and Analysis of Research Data.PMC4864874R155-2014-1724Sourander ASteadman CPetersson GGissler MCarter KWSusser ESuren PReichenberg ASchendel DESandin SHammond GHornig MLangridge ANewman SGross RSylvester Vethanayagam ASchalkwyk LSuominen AParner ETFrancis RWHultman CMYusof ZInternational Collaboration for Autism Registry EpidemiologyGunnes NHuttunen JGronborg TKBresnahan MLeonard HStoltenberg CfalseViPAR: a software platform for the Virtual Pooling and Analysis of Research Data.<h4>Background</h4>Research studies exploring the determinants of disease require sufficient statistical power to detect meaningful effects. Sample size is often increased through centralized pooling of disparately located datasets, though ethical, privacy and data ownership issues can often hamper this process. Methods that facilitate the sharing of research data that are sympathetic with these issues and which allow flexible and detailed statistical analyses are therefore in critical need. We have created a software platform for the Virtual Pooling and Analysis of Research data (ViPAR), which employs free and open source methods to provide researchers with a web-based platform to analyse datasets housed in disparate locations.<h4>Methods</h4>Database federation permits controlled access 2016-01-01T00:00:00Z2016 Apr2025-04-19T14:46:15.661Z2019-03-26T23:05:29ZS-EPMC48648742645238810.1093/ije/dyv193