{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schild M"],"funding":["Bundesinstitut für Sportwissenschaft"],"pagination":["4851935"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4867072"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2016"],"pubmed_abstract":["Acute physical exercise and repeated exercise stimuli affect whole-body metabolic and immunologic homeostasis. The aim of this study was to determine plasma protein profiles of trained (EET, n = 19) and untrained (SED, n = 17) individuals at rest and in response to an acute bout of endurance exercise. Participants completed a bicycle exercise test at an intensity corresponding to 80% of their VO2max. Plasma samples were taken before, directly after, and three hours after exercise and analyzed using multiplex immunoassays. Seventy-eight plasma variables were included in the final analysis. Twenty-nine variables displayed significant acute exercise effects in both groups. Seven proteins differed between groups, without being affected by acute exercise. Among these A2Macro and IL-5 were higher in EET individuals while leptin showed elevated levels in SED individuals. Fifteen variables revealed group and time differences with elevated levels for IL-3, IL-7, IL-10, and TNFR2 in EET individuals. An interaction effect could be observed for nine variables including IL-6, MMP-2, MMP-3, and muscle damage markers. The proteins that differ between groups indicate a long-term exercise effect on plasma protein concentrations. These findings might be of importance in the development of exercise-based strategies in the prevention and therapy of chronic metabolic and inflammatory diseases and for training monitoring."],"journal":["Mediators of inflammation"],"pubmed_title":["Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time."],"pmcid":["PMC4867072"],"funding_grant_id":["AZ 081902/09-13","FKZ 2509BI1902"],"pubmed_authors":["Kruger K","Eichner G","Zugel M","Krumholz-Wagner I","Pilat C","Steinacker JM","Hudemann J","Schild M","Mooren FC","Beiter T","Niess AM"],"additional_accession":[]},"is_claimable":false,"name":"Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time.","description":"Acute physical exercise and repeated exercise stimuli affect whole-body metabolic and immunologic homeostasis. The aim of this study was to determine plasma protein profiles of trained (EET, n = 19) and untrained (SED, n = 17) individuals at rest and in response to an acute bout of endurance exercise. Participants completed a bicycle exercise test at an intensity corresponding to 80% of their VO2max. Plasma samples were taken before, directly after, and three hours after exercise and analyzed using multiplex immunoassays. Seventy-eight plasma variables were included in the final analysis. Twenty-nine variables displayed significant acute exercise effects in both groups. Seven proteins differed between groups, without being affected by acute exercise. Among these A2Macro and IL-5 were higher in EET individuals while leptin showed elevated levels in SED individuals. Fifteen variables revealed group and time differences with elevated levels for IL-3, IL-7, IL-10, and TNFR2 in EET individuals. An interaction effect could be observed for nine variables including IL-6, MMP-2, MMP-3, and muscle damage markers. The proteins that differ between groups indicate a long-term exercise effect on plasma protein concentrations. These findings might be of importance in the development of exercise-based strategies in the prevention and therapy of chronic metabolic and inflammatory diseases and for training monitoring.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-04-05T14:58:46.88Z","creation":"2019-03-27T02:13:39Z"},"accession":"S-EPMC4867072","cross_references":{"pubmed":["27239103"],"doi":["10.1155/2016/4851935"]}}