biostudies-literatureBraxton DRNCI NIH HHS135-43https://www.ebi.ac.uk/biostudies/studies/S-EPMC4868088biostudies-literatureUnknown465(2)The esophageal submucosal glands (SMG) protect the squamous epithelium from insults such as gastroesophageal reflux disease by secreting mucins and bicarbonate. We have observed metaplastic changes within the SMG acini that we have termed oncocytic glandular metaplasia (OGM), and necrotizing sialometaplasia-like change (NSMLC). The aim of this study is to evaluate the associated clinicopathological parameters of, and to phenotypically characterize the SMG metaplasias. Esophagectomy specimens were retrospectively assessed on hematoxylin and eosin sections and assigned to either a Barrett's esophagus (BE) or non-BE control group. Clinicopathologic data was collected, and univariate analysis and multivariate logistic regression models were performed to assess the adjusted associations with NSVirchows Archiv : an international journal of pathologyNecrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus.PMC4868088P30 CA138292P30CA138292Liu YBraxton DRNickleach DCFarris ABfalseNecrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus.The esophageal submucosal glands (SMG) protect the squamous epithelium from insults such as gastroesophageal reflux disease by secreting mucins and bicarbonate. We have observed metaplastic changes within the SMG acini that we have termed oncocytic glandular metaplasia (OGM), and necrotizing sialometaplasia-like change (NSMLC). The aim of this study is to evaluate the associated clinicopathological parameters of, and to phenotypically characterize the SMG metaplasias. Esophagectomy specimens were retrospectively assessed on hematoxylin and eosin sections and assigned to either a Barrett's esophagus (BE) or non-BE control group. Clinicopathologic data was collected, and univariate analysis and multivariate logistic regression models were performed to assess the adjusted associations with NS2014-01-01T00:00:00Z2014 Aug2025-04-05T14:58:25.366Z2019-03-27T02:13:43ZS-EPMC48680882486324710.1007/s00428-014-1590-x