{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Grothe MJ"],"funding":["National Institute on Aging (NIA)","ADNI","Janssen Alzheimer Immunotherapy Research & Development, LLC","DOD ADNI","Merck & Co., Inc.","NIA NIH HHS","Eisai, Inc.","Meso Scale Diagnostics, LLC","National Institutes of Health","GE Healthcare","Alzheimer's Association","IXICO Ltd","National Institute on Aging","Eli Lilly and Company","Canadian Institutes of Health Research","Takeda Pharmaceutical Company","Alzheimer's Drug Discovery Foundation","Innogenetics, N.V.","Biogen Idec, Inc.","Northern California Institute for Research and Education","Interdisciplinary Faculty, Department “Individual and Societal Ageing,” University of Rostock","National Institute of Biomedical Imaging and Bioengineering","National Institute of Biomedical Imaging and Bioengineering (NIBIB)","Elan Pharmaceuticals, Inc.","NeuroRx Research; Novartis Pharmaceuticals Corporation","Medpace, Inc.","BioClinica, Inc.","Department of Defense","Bristol-Myers Squibb Company","Pfizer, Inc.","Piramal Imaging; Servier; Synarc, Inc.","Genentech, Inc.","Johnson & Johnson Pharmaceutical Research & Development LLC","F. Hoffmann-La Roche Ltd","Alzheimer's Disease Neuroimaging Initiative (ADNI)"],"pagination":["2411-2426"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4869802"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(6)"],"pubmed_abstract":["Degeneration of basal forebrain (BF) cholinergic nuclei is associated with cognitive decline, and this effect is believed to be mediated by neuronal dysfunction in the denervated cortical areas. MRI-based measurements of BF atrophy are increasingly being used as in vivo surrogate markers for cholinergic degeneration, but the functional implications of reductions in BF volume are not well understood. We used high-resolution MRI, fluorodeoxyglucose-positron emission tomography (PET), and neuropsychological test data of 132 subjects with mild cognitive impairment (MCI) and 177 cognitively normal controls to determine associations between BF atrophy, cortical hypometabolism, and cognitive deficits. BF atrophy in MCI correlated with both impaired memory function and attentional control deficits, whereas hippocampus volume was more specifically associated with memory deficits. BF atrophy was also associated with widespread cortical hypometabolism, and path analytic models indicated that hypometabolism in domain-specific cortical networks mediated the association between BF volume and cognitive dysfunction. The presence of cortical amyloid pathology, as assessed using AV45-PET, did not significantly interact with the observed associations. These data underline the potential of multimodal imaging markers to study structure-function-cognition relationships in the living human brain and provide important in vivo evidence for an involvement of the human BF in cortical activity and cognitive function."],"journal":["Cerebral cortex (New York, N.Y. : 1991)"],"pubmed_title":["Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment."],"pmcid":["PMC4869802"],"funding_grant_id":["U01 AG024904","R01 AG040311","W81XWH-12-2-0012"],"pubmed_authors":["Teipel SJ","Amaro E","Grinberg LT","Grothe MJ","Heinsen H"],"additional_accession":[]},"is_claimable":false,"name":"Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment.","description":"Degeneration of basal forebrain (BF) cholinergic nuclei is associated with cognitive decline, and this effect is believed to be mediated by neuronal dysfunction in the denervated cortical areas. MRI-based measurements of BF atrophy are increasingly being used as in vivo surrogate markers for cholinergic degeneration, but the functional implications of reductions in BF volume are not well understood. We used high-resolution MRI, fluorodeoxyglucose-positron emission tomography (PET), and neuropsychological test data of 132 subjects with mild cognitive impairment (MCI) and 177 cognitively normal controls to determine associations between BF atrophy, cortical hypometabolism, and cognitive deficits. BF atrophy in MCI correlated with both impaired memory function and attentional control deficits, whereas hippocampus volume was more specifically associated with memory deficits. BF atrophy was also associated with widespread cortical hypometabolism, and path analytic models indicated that hypometabolism in domain-specific cortical networks mediated the association between BF volume and cognitive dysfunction. The presence of cortical amyloid pathology, as assessed using AV45-PET, did not significantly interact with the observed associations. These data underline the potential of multimodal imaging markers to study structure-function-cognition relationships in the living human brain and provide important in vivo evidence for an involvement of the human BF in cortical activity and cognitive function.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jun","modification":"2025-04-04T09:36:30.233Z","creation":"2019-03-27T02:13:52Z"},"accession":"S-EPMC4869802","cross_references":{"pubmed":["25840425"],"doi":["10.1093/cercor/bhv062"]}}