biostudies-literatureUnknown26(6)Saitovitch AFondation OrangeAP-HP PHRCFondation de FranceParis Institute of Translational NeuroscienceInvestissements d'avenirProcessing eye-gaze information is a key step to human social interaction. Neuroimaging studies have shown that superior temporal sulcus (STS) is highly implicated in eye-gaze perception. In autism, a lack of preference for the eyes, as well as anatomo-functional abnormalities within the STS, has been described. To date, there are no experimental data in humans showing whether it is possible to interfere with eye-gaze processing by modulating STS neural activity. Here, we measured eye-gaze perception before and after inhibitory transcranial magnetic stimulation (TMS) applied over the posterior STS (pSTS) in young healthy volunteers. Eye-gaze processing, namely overt orienting toward the eyes, was measured using eye tracking during passive visualization of social movies. Inhibition of the rCerebral cortex (New York, N.Y. : 1991)2823-31https://www.ebi.ac.uk/biostudies/studies/S-EPMC4869819biostudies-literatureTuning Eye-Gaze Perception by Transitory STS Inhibition.PMC4869819Saitovitch APopa TRechtman EBrunelle FGrevent DZilbovicius MMeunier SCalmon RSamson YBoddaert NLemaitre HLamy JCfalseTuning Eye-Gaze Perception by Transitory STS Inhibition.Processing eye-gaze information is a key step to human social interaction. Neuroimaging studies have shown that superior temporal sulcus (STS) is highly implicated in eye-gaze perception. In autism, a lack of preference for the eyes, as well as anatomo-functional abnormalities within the STS, has been described. To date, there are no experimental data in humans showing whether it is possible to interfere with eye-gaze processing by modulating STS neural activity. Here, we measured eye-gaze perception before and after inhibitory transcranial magnetic stimulation (TMS) applied over the posterior STS (pSTS) in young healthy volunteers. Eye-gaze processing, namely overt orienting toward the eyes, was measured using eye tracking during passive visualization of social movies. Inhibition of the r2016-01-01T00:00:00Z2016 Jun2025-04-04T09:36:32.979Z2019-03-27T02:13:53ZS-EPMC48698192694613010.1093/cercor/bhw045