biostudies-literatureBagatell RNCATS NIH HHSNCI NIH HHS740-6https://www.ebi.ac.uk/biostudies/studies/S-EPMC4872026biostudies-literatureUnknown34(7)<h4>Purpose</h4>The International Neuroblastoma Response Criteria (INRC) require serial measurements of primary tumors in three dimensions, whereas the Response Evaluation Criteria in Solid Tumors (RECIST) require measurement in one dimension. This study was conducted to identify the preferred method of primary tumor response assessment for use in revised INRC.<h4>Patients and methods</h4>Patients younger than 20 years with high-risk neuroblastoma were eligible if they were diagnosed between 2000 and 2012 and if three primary tumor measurements (antero-posterior, width, cranio-caudal) were recorded at least twice before resection. Responses were defined as ≥ 30% reduction in longest dimension as per RECIST, ≥ 50% reduction in volume as per INRC, or ≥ 65% reduction in volume.<h4>Results</h4Journal of clinical oncology : official journal of the American Society of Clinical OncologyAssessment of Primary Site Response in Children With High-Risk Neuroblastoma: An International Multicenter Study.PMC4872026U10 CA098543U10 CA98543U10 CA180899U10 CA098413UL1 TR001427U10 CA98413Sarnacki SKammer BKrug BGranata Cvon Schweinitz DVolchenboum SLNaranjo ASimon TMcHugh KPark JRRojas YStates LJLyons KABrock PNuchtern JBagatell RPio LKirby CValteau-Couanet DVan Ryn CMiller AfalseAssessment of Primary Site Response in Children With High-Risk Neuroblastoma: An International Multicenter Study.<h4>Purpose</h4>The International Neuroblastoma Response Criteria (INRC) require serial measurements of primary tumors in three dimensions, whereas the Response Evaluation Criteria in Solid Tumors (RECIST) require measurement in one dimension. This study was conducted to identify the preferred method of primary tumor response assessment for use in revised INRC.<h4>Patients and methods</h4>Patients younger than 20 years with high-risk neuroblastoma were eligible if they were diagnosed between 2000 and 2012 and if three primary tumor measurements (antero-posterior, width, cranio-caudal) were recorded at least twice before resection. Responses were defined as ≥ 30% reduction in longest dimension as per RECIST, ≥ 50% reduction in volume as per INRC, or ≥ 65% reduction in volume.<h4>Results</h42016-01-01T00:00:00Z2016 Mar2025-06-01T12:01:30.298Z2025-06-01T12:01:30.298ZS-EPMC48720262675551510.1200/JCO.2015.63.204210.1200/jco.2015.63.2042