{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Wang LF"],"pubmed_abstract":["Men have worse survival than premenopausal women after intracerebral hemorrhage (ICH). After ICH, overproduction of iron associated with induction of heme oxygenase-1 (HO-1) in brain was observed. Rodent ICH model using ferrous citrate (FC)-infusion into the striatum to simulate iron overload, showed a higher degree of injury severity in males than in females. However, the participation of HO-1 in sex-differences of iron-induced brain injury remains unknown. The present results showed a higher level of HO-1 expression associated with more severe injury in males compared with females after FC-infusion. Estradiol (E2) contributed to lower levels of FC-induced HO-1 expression in females compared with males. Heterozygote ho-1 KO decreased the levels of FC-induced injury severity, histological "],"journal":["Scientific reports"],"pagination":["26358"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4873828"],"repository":["biostudies-literature"],"pubmed_title":["Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice."],"pmcid":["PMC4873828"],"pubmed_authors":["Yokoyama KK","Hsu C","Lin CL","Hsiao HW","Wang LF","Chiang PC","Chen TY"],"additional_accession":[]},"is_claimable":false,"name":"Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice.","description":"Men have worse survival than premenopausal women after intracerebral hemorrhage (ICH). After ICH, overproduction of iron associated with induction of heme oxygenase-1 (HO-1) in brain was observed. Rodent ICH model using ferrous citrate (FC)-infusion into the striatum to simulate iron overload, showed a higher degree of injury severity in males than in females. However, the participation of HO-1 in sex-differences of iron-induced brain injury remains unknown. The present results showed a higher level of HO-1 expression associated with more severe injury in males compared with females after FC-infusion. Estradiol (E2) contributed to lower levels of FC-induced HO-1 expression in females compared with males. Heterozygote ho-1 KO decreased the levels of FC-induced injury severity, histological ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2026-05-05T14:43:03.643Z","creation":"2026-04-07T21:46:38.89Z"},"accession":"S-EPMC4873828","cross_references":{"pubmed":["27198537"],"doi":["10.1038/srep26358"]}}