biostudies-literaturePajares MJNCI NIH HHS1129-36https://www.ebi.ac.uk/biostudies/studies/S-EPMC4874209biostudies-literatureUnknown30(10)<h4>Purpose</h4>Antiangiogenic therapies targeting the vascular endothelial growth factor (VEGF) pathway have yielded more modest clinical benefit to patients with non-small-cell lung cancer (NSCLC) than initially expected. Clinical data suggest a distinct biologic role of the VEGF pathway in the different histologic subtypes of lung cancer. To clarify the influence of histologic differentiation in the prognostic relevance of VEGF-mediated signaling in NSCLC, we performed a concomitant analysis of the expression of three key elements of the VEGF pathway in the earliest stages of the following two principal histologic subtypes: squamous cell carcinoma (SCC) and adenocarcinoma (ADC).<h4>Patients and methods</h4>We evaluated tumor cell expression of VEGF, VEGF receptor (VEGFR) 1, and VEGFR2 uJournal of clinical oncology : official journal of the American Society of Clinical OncologyExpression of tumor-derived vascular endothelial growth factor and its receptors is associated with outcome in early squamous cell carcinoma of the lung.PMC4874209P50 CA070907P30 CA016672Pajares MJMontuenga LMWistuba IIZudaire ITimsit JFEzponda TBrambilla CLarrayoz MBehrens CBrambilla ETorre WPio RAgorreta JVesin ALozano MDField JKfalseExpression of tumor-derived vascular endothelial growth factor and its receptors is associated with outcome in early squamous cell carcinoma of the lung.<h4>Purpose</h4>Antiangiogenic therapies targeting the vascular endothelial growth factor (VEGF) pathway have yielded more modest clinical benefit to patients with non-small-cell lung cancer (NSCLC) than initially expected. Clinical data suggest a distinct biologic role of the VEGF pathway in the different histologic subtypes of lung cancer. To clarify the influence of histologic differentiation in the prognostic relevance of VEGF-mediated signaling in NSCLC, we performed a concomitant analysis of the expression of three key elements of the VEGF pathway in the earliest stages of the following two principal histologic subtypes: squamous cell carcinoma (SCC) and adenocarcinoma (ADC).<h4>Patients and methods</h4>We evaluated tumor cell expression of VEGF, VEGF receptor (VEGFR) 1, and VEGFR2 u2012-01-01T00:00:00Z2012 Apr2026-06-04T15:34:02.835Z2019-03-27T02:14:11ZS-EPMC48742092235505610.1200/JCO.2011.37.423110.1200/jco.2011.37.4231