{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1(3)"],"submitter":["Mi Z"],"pubmed_abstract":["Retinoic acid-inducible gene-I (RIG-I) functions as an intracellular pattern recognition receptor (PRR) that recognizes the 5'-triphosphate moiety of single-stranded RNA viruses to initiate the innate immune response. Previous studies have shown that Lys63-linked ubiquitylation is required for RIG-I activation and the downstream anti-viral type I interferon (IFN-I) induction. Herein we reported that, RIG-I was also modified by small ubiquitin-like modifier-1 (SUMO-1). Functional analysis showed that RIG-I SUMOylation enhanced IFN-I production through increased ubiquitylation and the interaction with its downstream adaptor molecule Cardif. Our results therefore suggested that SUMOylation might serve as an additional regulatory tier for RIG-I activation and IFN-I signaling."],"journal":["Protein & cell"],"pagination":["275-83"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4875083"],"repository":["biostudies-literature"],"pubmed_title":["SUMOylation of RIG-I positively regulates the type I interferon signaling."],"pmcid":["PMC4875083"],"pubmed_authors":["Xiong Y","Mi Z","Fu J","Tang H"],"additional_accession":[]},"is_claimable":false,"name":"SUMOylation of RIG-I positively regulates the type I interferon signaling.","description":"Retinoic acid-inducible gene-I (RIG-I) functions as an intracellular pattern recognition receptor (PRR) that recognizes the 5'-triphosphate moiety of single-stranded RNA viruses to initiate the innate immune response. Previous studies have shown that Lys63-linked ubiquitylation is required for RIG-I activation and the downstream anti-viral type I interferon (IFN-I) induction. Herein we reported that, RIG-I was also modified by small ubiquitin-like modifier-1 (SUMO-1). Functional analysis showed that RIG-I SUMOylation enhanced IFN-I production through increased ubiquitylation and the interaction with its downstream adaptor molecule Cardif. Our results therefore suggested that SUMOylation might serve as an additional regulatory tier for RIG-I activation and IFN-I signaling.","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Mar","modification":"2025-04-22T06:16:15.703Z","creation":"2019-03-27T02:14:14Z"},"accession":"S-EPMC4875083","cross_references":{"pubmed":["21203974"],"doi":["10.1007/s13238-010-0030-1"]}}