{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kawalkowska J"],"funding":["Cancer Research UK","Rosetrees Trust","Versus Arthritis","Medical Research Council","NIGMS NIH HHS"],"pagination":["26430"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4876390"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["Proteins containing citrulline, a post-translational modification of arginine, are generated by peptidyl arginine deiminases (PAD). Citrullinated proteins have pro-inflammatory effects in both innate and adaptive immune responses. Here, we examine the therapeutic effects in collagen-induced arthritis of the second generation PAD inhibitor, BB-Cl-amidine. Treatment after disease onset resulted in the reversal of clinical and histological changes of arthritis, associated with a marked reduction in citrullinated proteins in lymph nodes. There was little overall change in antibodies to collagen or antibodies to citrullinated peptides, but a shift from pro-inflammatory Th1 and Th17-type responses to pro-resolution Th2-type responses was demonstrated by serum cytokines and antibody subtypes. In "],"journal":["Scientific reports"],"pubmed_title":["Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses."],"pmcid":["PMC4876390"],"funding_grant_id":["G1000807","R01 GM079357","G9400953","G0500905","M271-F1","13058","R01 GM110394","20776"],"pubmed_authors":["Subramanian V","Kawalkowska J","Williams RO","Ghari F","Fischer R","Davis S","Venables PJ","La Thangue NB","Quirke AM","Thompson PR"],"additional_accession":[]},"is_claimable":false,"name":"Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.","description":"Proteins containing citrulline, a post-translational modification of arginine, are generated by peptidyl arginine deiminases (PAD). Citrullinated proteins have pro-inflammatory effects in both innate and adaptive immune responses. Here, we examine the therapeutic effects in collagen-induced arthritis of the second generation PAD inhibitor, BB-Cl-amidine. Treatment after disease onset resulted in the reversal of clinical and histological changes of arthritis, associated with a marked reduction in citrullinated proteins in lymph nodes. There was little overall change in antibodies to collagen or antibodies to citrullinated peptides, but a shift from pro-inflammatory Th1 and Th17-type responses to pro-resolution Th2-type responses was demonstrated by serum cytokines and antibody subtypes. In ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2025-04-19T14:46:35.666Z","creation":"2019-03-27T02:14:17Z"},"accession":"S-EPMC4876390","cross_references":{"pubmed":["27210478"],"doi":["10.1038/srep26430"]}}