{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Chang YH"],"pubmed_abstract":["The repertoire of IgG antibody responses to infection and vaccination varies depending on the characteristics of the immunogen and the ability of the host to mount a protective immune response. Chronic hepatitis B virus (HBV) infections are marked by persistent infection and immune tolerance to vaccination. This disease offers a unique opportunity to discover key repertoire signatures during infection and in response to vaccination. Complementarity determining region 3 of an antibody heavy chain (CDR-H3) has a major impact on the antigenic specificity of an antibody. We used next-generation sequencing to characterize the CDR-H3 sequences in paired siblings of 4 families in which only one member of each pair had chronic HBV infection. Blood samples were obtained before and 2 weeks after HBV"],"journal":["Scientific reports"],"pagination":["26556"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4879636"],"repository":["biostudies-literature"],"pubmed_title":["Network Signatures of IgG Immune Repertoires in Hepatitis B Associated Chronic Infection and Vaccination Responses."],"pmcid":["PMC4879636"],"pubmed_authors":["Chang YH","Ma KH","Hsieh TC","Tsai SF","Liu HH","Hsu WB","Kuan HC","Yang CH","Chao A"],"additional_accession":[]},"is_claimable":false,"name":"Network Signatures of IgG Immune Repertoires in Hepatitis B Associated Chronic Infection and Vaccination Responses.","description":"The repertoire of IgG antibody responses to infection and vaccination varies depending on the characteristics of the immunogen and the ability of the host to mount a protective immune response. Chronic hepatitis B virus (HBV) infections are marked by persistent infection and immune tolerance to vaccination. This disease offers a unique opportunity to discover key repertoire signatures during infection and in response to vaccination. Complementarity determining region 3 of an antibody heavy chain (CDR-H3) has a major impact on the antigenic specificity of an antibody. We used next-generation sequencing to characterize the CDR-H3 sequences in paired siblings of 4 families in which only one member of each pair had chronic HBV infection. Blood samples were obtained before and 2 weeks after HBV","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2026-05-30T08:48:55.084Z","creation":"2019-03-27T02:14:30Z"},"accession":"S-EPMC4879636","cross_references":{"pubmed":["27222149"],"doi":["10.1038/srep26556"]}}