biostudies-literatureUnknown6Chang YHThe repertoire of IgG antibody responses to infection and vaccination varies depending on the characteristics of the immunogen and the ability of the host to mount a protective immune response. Chronic hepatitis B virus (HBV) infections are marked by persistent infection and immune tolerance to vaccination. This disease offers a unique opportunity to discover key repertoire signatures during infection and in response to vaccination. Complementarity determining region 3 of an antibody heavy chain (CDR-H3) has a major impact on the antigenic specificity of an antibody. We used next-generation sequencing to characterize the CDR-H3 sequences in paired siblings of 4 families in which only one member of each pair had chronic HBV infection. Blood samples were obtained before and 2 weeks after HBVScientific reports26556https://www.ebi.ac.uk/biostudies/studies/S-EPMC4879636biostudies-literatureNetwork Signatures of IgG Immune Repertoires in Hepatitis B Associated Chronic Infection and Vaccination Responses.PMC4879636Chang YHMa KHHsieh TCTsai SFLiu HHHsu WBKuan HCYang CHChao AfalseNetwork Signatures of IgG Immune Repertoires in Hepatitis B Associated Chronic Infection and Vaccination Responses.The repertoire of IgG antibody responses to infection and vaccination varies depending on the characteristics of the immunogen and the ability of the host to mount a protective immune response. Chronic hepatitis B virus (HBV) infections are marked by persistent infection and immune tolerance to vaccination. This disease offers a unique opportunity to discover key repertoire signatures during infection and in response to vaccination. Complementarity determining region 3 of an antibody heavy chain (CDR-H3) has a major impact on the antigenic specificity of an antibody. We used next-generation sequencing to characterize the CDR-H3 sequences in paired siblings of 4 families in which only one member of each pair had chronic HBV infection. Blood samples were obtained before and 2 weeks after HBV2016-01-01T00:00:00Z2016 May2026-05-30T08:48:55.084Z2019-03-27T02:14:30ZS-EPMC48796362722214910.1038/srep26556