{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Lin L"],"pubmed_abstract":["Interleukin 37 (IL-37) has been reported to play a significant role in innate immune response and to be involved in several kinds of cancers. However, the investigation of association between IL-37 and oral mucosa carcinogenesis hasn't been clearly established. The aim of the study was to assess IL-37 expression and explore its role in oral mucosa carcinogenesis. The expression of IL-37 increased from normal control (NC) to Oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC). Moreover, statistically highly significant difference was present between scores of OLK with and without mild/moderate dysplasia (P < 0.001). In addition, IL-37 expression was lower in OSCC with lymph node metastasis than those without metastasis (P < 0.01). What's more, overexpression of IL-37 in RAW264.7 cells remarkably reduced the pseudopodia, vacuolization and the expression of IL-6, TNF-α, and IL-1β. Finally, we found IL-37 and its receptor IL-18Rα but not its binding partner IL-18BP have similar tissue location and expression trend in different stages of oral mucosa carcinogenesis. Overall, IL-37 can be used as a biomarker for early oral tumorigenesis and for malignant transformation risk assessment of premalignant lesions."],"journal":["Scientific reports"],"pagination":["26757"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4880905"],"repository":["biostudies-literature"],"pubmed_title":["Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma."],"pmcid":["PMC4880905"],"pubmed_authors":["Zhou M","Chen Q","Zhang D","Li J","Zeng X","Liu S","Liu D","Xu H","Lin L","Wang J","Ji N"],"additional_accession":[]},"is_claimable":false,"name":"Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma.","description":"Interleukin 37 (IL-37) has been reported to play a significant role in innate immune response and to be involved in several kinds of cancers. However, the investigation of association between IL-37 and oral mucosa carcinogenesis hasn't been clearly established. The aim of the study was to assess IL-37 expression and explore its role in oral mucosa carcinogenesis. The expression of IL-37 increased from normal control (NC) to Oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC). Moreover, statistically highly significant difference was present between scores of OLK with and without mild/moderate dysplasia (P < 0.001). In addition, IL-37 expression was lower in OSCC with lymph node metastasis than those without metastasis (P < 0.01). What's more, overexpression of IL-37 in RAW264.7 cells remarkably reduced the pseudopodia, vacuolization and the expression of IL-6, TNF-α, and IL-1β. Finally, we found IL-37 and its receptor IL-18Rα but not its binding partner IL-18BP have similar tissue location and expression trend in different stages of oral mucosa carcinogenesis. Overall, IL-37 can be used as a biomarker for early oral tumorigenesis and for malignant transformation risk assessment of premalignant lesions.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2026-05-05T14:52:56.921Z","creation":"2019-03-27T02:14:33Z"},"accession":"S-EPMC4880905","cross_references":{"pubmed":["27225603"],"doi":["10.1038/srep26757"]}}