biostudies-literatureUnknown11(5)Zeng WFOBJECTIVE:To investigate the relationship between adiposity measures and plasma concentration of high molecular weight (HMW) adiponectin. METHODS:In a Chinese sample (n = 1081), we performed measurements of anthropometry and bioelectrical impedance analysis (BIA). We defined overweight and obesity as a body mass index between 24 and 27.4 kg/m² and ? 27.5 kg/m², respectively, and central obesity as a waist circumference ? 90 cm in men and ? 80 cm in women. Plasma HMW adiponectin concentration was measured by the ELISA method. RESULTS:Plasma HMW adiponectin concentration was significantly (P < 0.0001) higher in women (n = 677, 2.47 ?g/mL) than men (n = 404, 1.58 ?g/mL) and correlated with advancing age in men (r = 0.28) and women (r = 0.29). In adjusted analyses, it was lower in the presence of overweight (n = 159, 1.26 ?g/mL in men and n = 227, 2.15?g/mL in women) and obesity (n = 60, 1.31 ?g/mL and n = 82, 2.10 ?g/mL, respectively) than normal weight subjects (n = 185, 2.07?g/mL and n = 368, 2.94 ?g/mL, respectively) and in the presence of central obesity (n = 106, 1.28 ?g/mL and n = 331, 2.12 ?g/mL, respectively) than subjects with a normal waist circumference (n = 298, 1.74 ?g/mL and n = 346, 2.74 ?g/mL, respectively). In multiple regression analyses stratified for gender, adjusted for confounders and considered separately each of the adiposity measures, all adiposity measures were significantly (r -0.18 to -0.31, P < 0.001) associated with plasma HMW adiponectin concentration. However, in further stratified and adjusted regression analyses considered stepwise all adiposity measures, only waist-to-hip ratio was significantly (P < 0.05) associated with plasma HMW adiponectin concentration in men (r = -0.10) and women (r = -0.15). CONCLUSIONS:Anthropometric measures of obesity, such as waist-to-hip ratio, but not BIA measures, are independently associated with plasma adiponectin concentration.PloS onee0156041https://www.ebi.ac.uk/biostudies/studies/S-EPMC4882000biostudies-literatureAssociation of Anthropometric and Bioelectrical Impedance Analysis Measures of Adiposity with High Molecular Weight Adiponectin Concentration.PMC4882000Li YWang SSheng CSKang YYLi FKHuang QFZhang LWang JGZeng WFCheng YBfalseAssociation of Anthropometric and Bioelectrical Impedance Analysis Measures of Adiposity with High Molecular Weight Adiponectin Concentration.OBJECTIVE:To investigate the relationship between adiposity measures and plasma concentration of high molecular weight (HMW) adiponectin. METHODS:In a Chinese sample (n = 1081), we performed measurements of anthropometry and bioelectrical impedance analysis (BIA). We defined overweight and obesity as a body mass index between 24 and 27.4 kg/m² and ? 27.5 kg/m², respectively, and central obesity as a waist circumference ? 90 cm in men and ? 80 cm in women. Plasma HMW adiponectin concentration was measured by the ELISA method. RESULTS:Plasma HMW adiponectin concentration was significantly (P < 0.0001) higher in women (n = 677, 2.47 ?g/mL) than men (n = 404, 1.58 ?g/mL) and correlated with advancing age in men (r = 0.28) and women (r = 0.29). In adjusted analyses, it was lower in the presence of overweight (n = 159, 1.26 ?g/mL in men and n = 227, 2.15?g/mL in women) and obesity (n = 60, 1.31 ?g/mL and n = 82, 2.10 ?g/mL, respectively) than normal weight subjects (n = 185, 2.07?g/mL and n = 368, 2.94 ?g/mL, respectively) and in the presence of central obesity (n = 106, 1.28 ?g/mL and n = 331, 2.12 ?g/mL, respectively) than subjects with a normal waist circumference (n = 298, 1.74 ?g/mL and n = 346, 2.74 ?g/mL, respectively). In multiple regression analyses stratified for gender, adjusted for confounders and considered separately each of the adiposity measures, all adiposity measures were significantly (r -0.18 to -0.31, P < 0.001) associated with plasma HMW adiponectin concentration. However, in further stratified and adjusted regression analyses considered stepwise all adiposity measures, only waist-to-hip ratio was significantly (P < 0.05) associated with plasma HMW adiponectin concentration in men (r = -0.10) and women (r = -0.15). CONCLUSIONS:Anthropometric measures of obesity, such as waist-to-hip ratio, but not BIA measures, are independently associated with plasma adiponectin concentration.2016-01-01T00:00:00Z20162021-02-20T11:54:08Z2019-03-26T22:51:53ZS-EPMC48820002722768010.1371/journal.pone.0156041