{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(11)"],"submitter":["Nord H"],"pubmed_abstract":["The pigment pattern of many animal species is a result of the arrangement of different types of pigment-producing chromatophores. The zebrafish has three different types of chromatophores: black melanophores, yellow xanthophores, and shimmering iridophores arranged in a characteristic pattern of golden and blue horizontal stripes. In the zebrafish embryo, chromatophores derive from the neural crest cells. Using pax7a and pax7b zebrafish mutants, we identified a previously unknown requirement for Pax7 in xanthophore lineage formation. The absence of Pax7 results in a severe reduction of xanthophore precursor cells and a complete depletion of differentiated xanthophores in embryos as well as in adult zebrafish. In contrast, the melanophore lineage is increased in pax7a/pax7b double-mutant embryos and larvae, whereas juvenile and adult pax7a/pax7b double-mutant zebrafish display a severe decrease in melanophores and a pigment pattern disorganization indicative of a xanthophore- deficient phenotype. In summary, we propose a novel role for Pax7 in the early specification of chromatophore precursor cells."],"journal":["Molecular biology of the cell"],"pagination":["1853-62"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4884075"],"repository":["biostudies-literature"],"pubmed_title":["Pax7 is required for establishment of the xanthophore lineage in zebrafish embryos."],"pmcid":["PMC4884075"],"pubmed_authors":["Nord H","von Hofsten J","Dennhag N","Muck J"],"additional_accession":[]},"is_claimable":false,"name":"Pax7 is required for establishment of the xanthophore lineage in zebrafish embryos.","description":"The pigment pattern of many animal species is a result of the arrangement of different types of pigment-producing chromatophores. The zebrafish has three different types of chromatophores: black melanophores, yellow xanthophores, and shimmering iridophores arranged in a characteristic pattern of golden and blue horizontal stripes. In the zebrafish embryo, chromatophores derive from the neural crest cells. Using pax7a and pax7b zebrafish mutants, we identified a previously unknown requirement for Pax7 in xanthophore lineage formation. The absence of Pax7 results in a severe reduction of xanthophore precursor cells and a complete depletion of differentiated xanthophores in embryos as well as in adult zebrafish. In contrast, the melanophore lineage is increased in pax7a/pax7b double-mutant embryos and larvae, whereas juvenile and adult pax7a/pax7b double-mutant zebrafish display a severe decrease in melanophores and a pigment pattern disorganization indicative of a xanthophore- deficient phenotype. In summary, we propose a novel role for Pax7 in the early specification of chromatophore precursor cells.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jun","modification":"2024-11-09T10:13:15.172Z","creation":"2019-03-27T02:14:43Z"},"accession":"S-EPMC4884075","cross_references":{"pubmed":["27053658"],"doi":["10.1091/mbc.E15-12-0821"]}}