biostudies-literatureAojula ASir Arthur Thompson TrustDepartment of Neurosurgery, Washington University School of MedicinePediatric Hydrocephalus AssociationMedical Research CouncilNational Institute for Health Research (NIHR)University of Utah Vice President for ResearchDepartment of Neurosurgery, University of UtahBiotechnology and Biological Sciences Research Council9https://www.ebi.ac.uk/biostudies/studies/S-EPMC4888658biostudies-literatureUnknown13(1)<h4>Background</h4>In an effort to develop novel treatments for communicating hydrocephalus, we have shown previously that the transforming growth factor-β antagonist, decorin, inhibits subarachnoid fibrosis mediated ventriculomegaly; however decorin's ability to prevent cerebral cytopathology in communicating hydrocephalus has not been fully examined. Furthermore, the capacity for diffusion tensor imaging to act as a proxy measure of cerebral pathology in multiple sclerosis and spinal cord injury has recently been demonstrated. However, the use of diffusion tensor imaging to investigate cytopathological changes in communicating hydrocephalus is yet to occur. Hence, this study aimed to determine whether decorin treatment influences alterations in diffusion tensor imaging parameters and cytFluids and barriers of the CNSDiffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus.PMC4888658CL-2009-09-001MR/K015184/1MR/N019016/1NIHR-CS-011-028Gonzalez AMSinclair ABotfield HAbdullah OAojula ALogan AMcAllister JPfalseDiffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus.<h4>Background</h4>In an effort to develop novel treatments for communicating hydrocephalus, we have shown previously that the transforming growth factor-β antagonist, decorin, inhibits subarachnoid fibrosis mediated ventriculomegaly; however decorin's ability to prevent cerebral cytopathology in communicating hydrocephalus has not been fully examined. Furthermore, the capacity for diffusion tensor imaging to act as a proxy measure of cerebral pathology in multiple sclerosis and spinal cord injury has recently been demonstrated. However, the use of diffusion tensor imaging to investigate cytopathological changes in communicating hydrocephalus is yet to occur. Hence, this study aimed to determine whether decorin treatment influences alterations in diffusion tensor imaging parameters and cyt2016-01-01T00:00:00Z2016 May2026-07-15T21:23:02.27Z2026-07-09T10:13:37.403ZS-EPMC48886582724683710.1186/s12987-016-0033-2