{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(5)"],"submitter":["Roche SL"],"pubmed_abstract":["Background
Angiotensin-converting enzyme inhibitors (ACEIs) are a mainstay of medical management in pediatric cardiology. However, there are no data defining how best to initiate and uptitrate the dose of these medications in children.Methods and results
Retrospective chart review revealed only 24% of our pediatric cardiology inpatients were discharged on predefined optimal doses of ACEIs and few underwent further dose uptitration in the 8 weeks after hospital discharge. Therefore, 2 alternative protocols for initiation of captopril were compared in a prospective randomized clinical trial. A \"rapid uptitration\" protocol reached an optimal dose on day 3, whereas the alternative, \"prolonged uptitration\" protocol, reached an optimal dose on day 9. Forty-6 patients (54% male) w"],"journal":["Journal of the American Heart Association"],"pagination":["e003230"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4889193"],"repository":["biostudies-literature"],"pubmed_title":["Angiotensin-Converting Enzyme Inhibitor Initiation and Dose Uptitration in Children With Cardiovascular Disease: A Retrospective Review of Standard Clinical Practice and a Prospective Randomized Clinical Trial."],"pmcid":["PMC4889193"],"pubmed_authors":["Manlhiot C","Timberlake K","George K","Kantor PF","Wilson J","Roche SL","Balasingam M","McCrindle BW"],"additional_accession":[]},"is_claimable":false,"name":"Angiotensin-Converting Enzyme Inhibitor Initiation and Dose Uptitration in Children With Cardiovascular Disease: A Retrospective Review of Standard Clinical Practice and a Prospective Randomized Clinical Trial.","description":"Background
Angiotensin-converting enzyme inhibitors (ACEIs) are a mainstay of medical management in pediatric cardiology. However, there are no data defining how best to initiate and uptitrate the dose of these medications in children.Methods and results
Retrospective chart review revealed only 24% of our pediatric cardiology inpatients were discharged on predefined optimal doses of ACEIs and few underwent further dose uptitration in the 8 weeks after hospital discharge. Therefore, 2 alternative protocols for initiation of captopril were compared in a prospective randomized clinical trial. A \"rapid uptitration\" protocol reached an optimal dose on day 3, whereas the alternative, \"prolonged uptitration\" protocol, reached an optimal dose on day 9. Forty-6 patients (54% male) w","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2026-05-30T03:41:30.525Z","creation":"2019-03-27T02:14:59Z"},"accession":"S-EPMC4889193","cross_references":{"pubmed":["27207965"],"doi":["10.1161/JAHA.116.003230"]}}