biostudies-literatureGirotra SNHLBI NIH HHS2159-68https://www.ebi.ac.uk/biostudies/studies/S-EPMC4889467biostudies-literatureUnknown133(22)<h4>Background</h4>Although previous studies have shown marked variation in out-of-hospital cardiac arrest survival across US regions, factors underlying this survival variation remain incompletely explained.<h4>Methods and results</h4>Using data from the Cardiac Arrest Registry to Enhance Survival, we identified 96 662 adult patients with out-of-hospital cardiac arrest in 132 US counties. We used hierarchical regression models to examine county-level variation in rates of survival and survival with functional recovery (defined as Cerebral Performance Category score of 1 or 2) and examined the contribution of demographics, cardiac arrest characteristics, bystander cardiopulmonary resuscitation, automated external defibrillator use, and county-level sociodemographic factors in survival variCirculationRegional Variation in Out-of-Hospital Cardiac Arrest Survival in the United States.PMC4889467K23 HL102224K08 HL122527R01 HL123980CARES Surveillance Group and the HeartRescue ProjectSasson CChan PSVellano KAnderson MLAbella BSMcNally BGirotra SCarrel Mvan Diepen SNallamothu BKfalseRegional Variation in Out-of-Hospital Cardiac Arrest Survival in the United States.<h4>Background</h4>Although previous studies have shown marked variation in out-of-hospital cardiac arrest survival across US regions, factors underlying this survival variation remain incompletely explained.<h4>Methods and results</h4>Using data from the Cardiac Arrest Registry to Enhance Survival, we identified 96 662 adult patients with out-of-hospital cardiac arrest in 132 US counties. We used hierarchical regression models to examine county-level variation in rates of survival and survival with functional recovery (defined as Cerebral Performance Category score of 1 or 2) and examined the contribution of demographics, cardiac arrest characteristics, bystander cardiopulmonary resuscitation, automated external defibrillator use, and county-level sociodemographic factors in survival vari2016-01-01T00:00:00Z2016 May2025-04-04T02:35:57.072Z2025-04-04T02:35:57.072ZS-EPMC48894672708111910.1161/circulationaha.115.01817510.1161/CIRCULATIONAHA.115.018175