{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zheng Y"],"funding":["NCRR NIH HHS","NIGMS NIH HHS"],"pagination":["2516-26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4891189"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(8)"],"pubmed_abstract":["<h4>Purpose</h4>Recent controversial publications, citing studies purporting to show that P-gp mediates the transport of propranolol, proposed that passive biological membrane transport is negligible. Based on the BDDCS, the extensively metabolized-highly permeable-highly soluble BDDCS class 1 drug, propranolol, shows a high passive permeability at concentrations unrestricted by solubility that can overwhelm any potential transporter effects. Here we reinvestigate the effects of passive diffusion and carrier-mediated transport on S-propranolol.<h4>Methods</h4>Bidirectional permeability and inhibition of efflux transport studies were carried out in MDCK, MDCK-MDR1 and Caco-2 cell lines at different concentrations. Transcellular permeability studies were conducted at different apical pHs in "],"journal":["Pharmaceutical research"],"pubmed_title":["pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion."],"pmcid":["PMC4891189"],"funding_grant_id":["U01 GM061390","R43 RR031474","U19 GM061390","RR031474","GM061390"],"pubmed_authors":["Zheng Y","Benet LZ","Chen X","Okochi H"],"additional_accession":[]},"is_claimable":false,"name":"pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion.","description":"<h4>Purpose</h4>Recent controversial publications, citing studies purporting to show that P-gp mediates the transport of propranolol, proposed that passive biological membrane transport is negligible. Based on the BDDCS, the extensively metabolized-highly permeable-highly soluble BDDCS class 1 drug, propranolol, shows a high passive permeability at concentrations unrestricted by solubility that can overwhelm any potential transporter effects. Here we reinvestigate the effects of passive diffusion and carrier-mediated transport on S-propranolol.<h4>Methods</h4>Bidirectional permeability and inhibition of efflux transport studies were carried out in MDCK, MDCK-MDR1 and Caco-2 cell lines at different concentrations. Transcellular permeability studies were conducted at different apical pHs in ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Aug","modification":"2025-04-04T02:35:54.176Z","creation":"2019-03-27T02:15:11Z"},"accession":"S-EPMC4891189","cross_references":{"pubmed":["25690341"],"doi":["10.1007/s11095-015-1640-3"]}}