{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Mourino-Alvarez L"],"pubmed_abstract":["Aortic stenosis (AS) is the most common form of valve disease. Once symptoms develop, there is an inexorable deterioration with a poor prognosis; currently there are no therapies capable of modifying disease progression, and aortic valve replacement is the only available treatment. Our goal is to study the progression of calcification by matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS) and get new insights at molecular level that could help in the understanding of this disease. In this work, we analyzed consecutive slices from aortic valve tissue by MALDI-IMS, to establish the spatial distribution of proteins and peptides directly from the surface of the histological sections. The analysis showed different structures corresponding to regions observed in con"],"journal":["Scientific reports"],"pagination":["27106"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4891820"],"repository":["biostudies-literature"],"pubmed_title":["MALDI-Imaging Mass Spectrometry: a step forward in the anatomopathological characterization of stenotic aortic valve tissue."],"pmcid":["PMC4891820"],"pubmed_authors":["Sanchez PL","Azkargorta M","Barderas MG","de la Cuesta F","Iloro I","Pinto A","Fernandez-Aviles F","Mourino-Alvarez L","Sastre-Oliva T","Lopez-Almodovar LF","Padial LR","Akerstrom F","Urreta H","Escobes I","Elortza F"],"additional_accession":[]},"is_claimable":false,"name":"MALDI-Imaging Mass Spectrometry: a step forward in the anatomopathological characterization of stenotic aortic valve tissue.","description":"Aortic stenosis (AS) is the most common form of valve disease. Once symptoms develop, there is an inexorable deterioration with a poor prognosis; currently there are no therapies capable of modifying disease progression, and aortic valve replacement is the only available treatment. Our goal is to study the progression of calcification by matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS) and get new insights at molecular level that could help in the understanding of this disease. In this work, we analyzed consecutive slices from aortic valve tissue by MALDI-IMS, to establish the spatial distribution of proteins and peptides directly from the surface of the histological sections. The analysis showed different structures corresponding to regions observed in con","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jun","modification":"2026-05-30T09:10:49.035Z","creation":"2019-03-27T02:15:15Z"},"accession":"S-EPMC4891820","cross_references":{"pubmed":["27256770"],"doi":["10.1038/srep27106"]}}