{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nie Y"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS"],"pagination":["409-19"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4891933"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(6)"],"pubmed_abstract":["Through linkage analysis of the Dahl salt-sensitive (S) rat and the spontaneously hypertensive rat (SHR), a blood pressure (BP) quantitative trait locus (QTL) was previously located on rat chromosome 9. Subsequent substitution mapping studies of this QTL revealed multiple BP QTLs within the originally identified logarithm of odds plot by linkage analysis. The focus of this study was on a 14.39 Mb region, the distal portion of which remained unmapped in our previous studies. High-resolution substitution mapping for a BP QTL in the setting of a high-salt diet indicated that an SHR-derived congenic segment of 787.9 kb containing the gene secreted phosphoprotein-2 (Spp2) lowered BP and urinary protein excretion. A nonsynonymous G/T polymorphism in the Spp2 gene was detected between the S and S"],"journal":["Physiological genomics"],"pubmed_title":["High-resolution mapping of a novel rat blood pressure locus on chromosome 9 to a region containing the Spp2 gene and colocalization of a QTL for bone mass."],"pmcid":["PMC4891933"],"funding_grant_id":["R01 HL020176","P30 DK020572","R01 HL112641","R37 HL020176","R01 HL076709"],"pubmed_authors":["Kumarasamy S","Joe B","Waghulde H","Lecka-Czernik B","Cheng X","Mell B","Czernik PJ","Nie Y"],"additional_accession":[]},"is_claimable":false,"name":"High-resolution mapping of a novel rat blood pressure locus on chromosome 9 to a region containing the Spp2 gene and colocalization of a QTL for bone mass.","description":"Through linkage analysis of the Dahl salt-sensitive (S) rat and the spontaneously hypertensive rat (SHR), a blood pressure (BP) quantitative trait locus (QTL) was previously located on rat chromosome 9. Subsequent substitution mapping studies of this QTL revealed multiple BP QTLs within the originally identified logarithm of odds plot by linkage analysis. The focus of this study was on a 14.39 Mb region, the distal portion of which remained unmapped in our previous studies. High-resolution substitution mapping for a BP QTL in the setting of a high-salt diet indicated that an SHR-derived congenic segment of 787.9 kb containing the gene secreted phosphoprotein-2 (Spp2) lowered BP and urinary protein excretion. A nonsynonymous G/T polymorphism in the Spp2 gene was detected between the S and S","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jun","modification":"2026-05-30T09:10:49.851Z","creation":"2019-03-27T02:15:15Z"},"accession":"S-EPMC4891933","cross_references":{"pubmed":["27113531"],"doi":["10.1152/physiolgenomics.00004.2016"]}}