biostudies-literatureLee AWIntramural NIH HHSCancer Research UKNIEHS NIH HHSThe Francis Crick InstituteNCI NIH HHSCIHR542-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC4892108biostudies-literatureUnknown136(3)<h4>Objective</h4>Ovarian cancer is a hormone-related disease with a strong genetic basis. However, none of its high-penetrance susceptibility genes and GWAS-identified variants to date are known to be involved in hormonal pathways. Given the hypothesized etiologic role of gonadotropins, an assessment of how variability in genes involved in the gonadotropin signaling pathway impacts disease risk is warranted.<h4>Methods</h4>Genetic data from 41 ovarian cancer study sites were pooled and unconditional logistic regression was used to evaluate whether any of the 2185 SNPs from 11 gonadotropin signaling pathway genes was associated with ovarian cancer risk. A burden test using the admixture likelihood (AML) method was also used to evaluate gene-level associations.<h4>Results</h4>We did not finGynecologic oncologyEvaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study.PMC4892108P01-CA017054R01-CA016056P30-CA072720P50 CA159981R01-CA063682R03 CA113148P50-CA159981R03-CA115195R01-CA080978N01-PC067010R01-CA063678MSH-8773416561R01-CA017054R01-CA061132K07-CA095666P30-CA008748R01 CA126841P50-CA136393P30-CA15083P50 CA136393R01 CA087538R01 CA141154R01-CA136924R01-CA087538R01-CA092044K22-CA138563R01-CA126841K07-CA80668R01-CA12244315960N01-PC67001R01-CA067262R01-CA058598R01-CA071766N01-CN55424K07-CA143047P30 CA071789R01-CA112523C490/A6187R01-CA114343R01-CA049449R01-CA014089P50-CA105009R03-CA113148R03 CA115195R01-CA058860P01-CA087696C490/A10124P30 CA072720R01-CA054419U01-CA069417R01-CA050385C490/A10119N01-PC035137R01-CA074850T32ES013678R01-CA083918U01-CA07196610124R01-CA061107Heitz FDork TSouthey MCSieh WMyers EJLubinski JNedergaard LWalsh CLiang DBjorge LGronwald JOdunsi KGentry-Maharaj ASalvesen HBLundvall LShvetsov YBBogdanova NEilber UEkici ABSpiewankiewicz BKelemen LEOrsulic SHillemanns PLester JTworoger SSModugno FHein APearce CLRudolph AKarlan BYLevine DATyrer JPVierkant RABisogna MHarrington PBean YDansonka-Mieszkowska APhelan CMVan Nieuwenhuysen ESchildkraut JMCarty KZiogas APelttari LMWang-Gohrke SGoodman MTCampbell IGWilkens LRHogdall CNess RBLambrechts DWicklund KGHogdall EWentzensen NWhittemore ASRisch HAWu AHdu Bois ACybulski CRossing MASiddiqui NPaul JLee AWWeber RPTangen ILPharoah PDPike MCHarter PChenevix-Trench GHildebrandt MAWu XPlisiecka-Halasa JKellar MYang HKiemeney LAChang-Claude JAustralian Ovarian Cancer Study GroupRunnebaum IBMassuger LFKupryjanczyk JFasching PASchwaab ILu KEccles DNevanlinna HThompson PJLeminen ABrooks-Wilson AKjaer SKBerchuck ALe NDPoole EMBrinton LAAnton-Culver HTerry KLCook LSDoherty JABandera EVOlson SHPejovic TJensen AKrakstad CMenon UBeckmann MWGiles GGRamus SJCunningham JMOrlow IMcLaughlin JRKelley JLAustralian Cancer Study (Ovarian Cancer)Durst MCramer DWStram DAMcGuire VAben KKMoysich KBSucheston-Campbell LVergote IEdwards RPStram DOSong Hvan Altena AMGlasspool RIversen ESRothstein JHMcNeish IAJakubowska AFridley BLLissowska JBruinsma FGoode ELfalseEvaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study.<h4>Objective</h4>Ovarian cancer is a hormone-related disease with a strong genetic basis. However, none of its high-penetrance susceptibility genes and GWAS-identified variants to date are known to be involved in hormonal pathways. Given the hypothesized etiologic role of gonadotropins, an assessment of how variability in genes involved in the gonadotropin signaling pathway impacts disease risk is warranted.<h4>Methods</h4>Genetic data from 41 ovarian cancer study sites were pooled and unconditional logistic regression was used to evaluate whether any of the 2185 SNPs from 11 gonadotropin signaling pathway genes was associated with ovarian cancer risk. A burden test using the admixture likelihood (AML) method was also used to evaluate gene-level associations.<h4>Results</h4>We did not fin2015-01-01T00:00:00Z2015 Mar2026-05-30T09:11:09.335Z2025-07-28T03:04:07.925ZS-EPMC48921082552849810.1016/j.ygyno.2014.12.017