{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(2)"],"submitter":["Trefz FM"],"pubmed_abstract":["<h4>Background</h4>Increased plasma potassium concentrations (K(+)) in neonatal calves with diarrhea are associated with acidemia and severe clinical dehydration and are therefore usually corrected by intravenous administration of fluids containing sodium bicarbonate.<h4>Objectives</h4>To identify clinical and laboratory variables that are associated with changes of plasma K(+) during the course of treatment and to document the plasma potassium-lowering effect of hypertonic (8.4%) sodium bicarbonate solutions.<h4>Animals</h4>Seventy-one neonatal diarrheic calves.<h4>Methods</h4>Prospective cohort study. Calves were treated according to a clinical protocol using an oral electrolyte solution and commercially available packages of 8.4% sodium bicarbonate (250-750 mmol), 0.9% saline (5-10 L), and 40% dextrose (0.5 L) infusion solutions.<h4>Results</h4>Infusions with 8.4% sodium bicarbonate solutions in an amount of 250-750 mmol had an immediate and sustained plasma potassium-lowering effect. One hour after the end of such infusions or the start of a sodium bicarbonate containing constant drip infusion, changes of plasma K(+) were most closely correlated to changes of venous blood pH, plasma sodium concentrations and plasma volume (r = -0.73, -0.57, -0.53; P < .001). Changes of plasma K(+) during the subsequent 23 hours were associated with changes of venous blood pH, clinical hydration status (enophthalmos) and serum creatinine concentrations (r = -0.71, 0.63, 0.62; P < .001).<h4>Conclusions and clinical importance</h4>This study emphasizes the importance of alkalinization and the correction of dehydration in the treatment of hyperkalemia in neonatal calves with diarrhea."],"journal":["Journal of veterinary internal medicine"],"pagination":["696-704"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4895490"],"repository":["biostudies-literature"],"pubmed_title":["Effects of alkalinization and rehydration on plasma potassium concentrations in neonatal calves with diarrhea."],"pmcid":["PMC4895490"],"pubmed_authors":["Kutschke A","Lorenz I","Zitzl J","Trefz FM","Lorch A","Knubben-Schweizer G"],"additional_accession":[]},"is_claimable":false,"name":"Effects of alkalinization and rehydration on plasma potassium concentrations in neonatal calves with diarrhea.","description":"<h4>Background</h4>Increased plasma potassium concentrations (K(+)) in neonatal calves with diarrhea are associated with acidemia and severe clinical dehydration and are therefore usually corrected by intravenous administration of fluids containing sodium bicarbonate.<h4>Objectives</h4>To identify clinical and laboratory variables that are associated with changes of plasma K(+) during the course of treatment and to document the plasma potassium-lowering effect of hypertonic (8.4%) sodium bicarbonate solutions.<h4>Animals</h4>Seventy-one neonatal diarrheic calves.<h4>Methods</h4>Prospective cohort study. Calves were treated according to a clinical protocol using an oral electrolyte solution and commercially available packages of 8.4% sodium bicarbonate (250-750 mmol), 0.9% saline (5-10 L), and 40% dextrose (0.5 L) infusion solutions.<h4>Results</h4>Infusions with 8.4% sodium bicarbonate solutions in an amount of 250-750 mmol had an immediate and sustained plasma potassium-lowering effect. One hour after the end of such infusions or the start of a sodium bicarbonate containing constant drip infusion, changes of plasma K(+) were most closely correlated to changes of venous blood pH, plasma sodium concentrations and plasma volume (r = -0.73, -0.57, -0.53; P < .001). Changes of plasma K(+) during the subsequent 23 hours were associated with changes of venous blood pH, clinical hydration status (enophthalmos) and serum creatinine concentrations (r = -0.71, 0.63, 0.62; P < .001).<h4>Conclusions and clinical importance</h4>This study emphasizes the importance of alkalinization and the correction of dehydration in the treatment of hyperkalemia in neonatal calves with diarrhea.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Mar-Apr","modification":"2021-02-21T08:23:22Z","creation":"2019-03-27T02:15:28Z"},"accession":"S-EPMC4895490","cross_references":{"pubmed":["25641097"],"doi":["10.1111/jvim.12537"]}}