biostudies-literatureGrupe DWNICHD NIH HHSNIMH NIH HHS1885-95https://www.ebi.ac.uk/biostudies/studies/S-EPMC4900910biostudies-literatureUnknown46(9)<h4>Background</h4>Previous research in post-traumatic stress disorder (PTSD) has identified disrupted ventromedial prefrontal cortex (vmPFC) function in those with v. without PTSD. It is unclear whether this brain region is uniformly affected in all individuals with PTSD, or whether vmPFC dysfunction is related to individual differences in discrete features of this heterogeneous disorder.<h4>Method</h4>In a sample of 51 male veterans of Operation Enduring Freedom/Operation Iraqi Freedom, we collected functional magnetic resonance imaging data during a novel threat anticipation task with crossed factors of threat condition and temporal unpredictability. Voxelwise regression analyses related anticipatory brain activation to individual differences in overall PTSD symptom severity, as well asPsychological medicineNeurobiological correlates of distinct post-traumatic stress disorder symptom profiles during threat anticipation in combat veterans.PMC4900910R01 MH043454T32 MH018931P30 HD003352Nitschke JBWielgosz JGrupe DWDavidson RJfalseNeurobiological correlates of distinct post-traumatic stress disorder symptom profiles during threat anticipation in combat veterans.<h4>Background</h4>Previous research in post-traumatic stress disorder (PTSD) has identified disrupted ventromedial prefrontal cortex (vmPFC) function in those with v. without PTSD. It is unclear whether this brain region is uniformly affected in all individuals with PTSD, or whether vmPFC dysfunction is related to individual differences in discrete features of this heterogeneous disorder.<h4>Method</h4>In a sample of 51 male veterans of Operation Enduring Freedom/Operation Iraqi Freedom, we collected functional magnetic resonance imaging data during a novel threat anticipation task with crossed factors of threat condition and temporal unpredictability. Voxelwise regression analyses related anticipatory brain activation to individual differences in overall PTSD symptom severity, as well as2016-01-01T00:00:00Z2016 Jul2025-04-04T02:43:07.594Z2019-03-27T02:15:44ZS-EPMC49009102697965910.1017/s003329171600037410.1017/S0033291716000374