{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kucuk C"],"funding":["National Institute for General Medical Science","National Center for Research Resources","NCRR NIH HHS","NIH Lymphoma Specialized Programs of Research Excellence","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["1435-41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4901131"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["186(6)"],"pubmed_abstract":["Natural killer/T-cell lymphoma (NKTCL) is a rare, aggressive form of non-Hodgkin lymphoma that is generally incurable at more advanced stages with systemic involvement. Clonal diagnostic markers (eg, unique T- or B-cell receptor rearrangements) are not available for NKTCLs. Killer cell immunoglobulin like receptors (KIRs) are a family of type I transmembrane glycoproteins involved in the inhibition or activation of NK cells. A restricted expression profile of KIRs has been proposed as clonal markers of NK-cell proliferations. Here we evaluated the transcription profile of all KIR family genes and C-type lectin receptor genes using RNA sequencing on NKTCL cases (n = 17) and NK-cell lines (n = 3). The expression of all KIRs tended to be markedly reduced or absent in NKTCL, except for the KIR"],"journal":["The American journal of pathology"],"pubmed_title":["Diagnostic and Biological Significance of KIR Expression Profile Determined by RNA-Seq in Natural Killer/T-Cell Lymphoma."],"pmcid":["PMC4901131"],"funding_grant_id":["P20 RR016469","P50 CA107399","5P20RR016469","P20 RR018788","P50CA136411-01 (W.C.C.)","P30 CA033572","RR018788-08","P50 CA136411","8P20GM103427","P20 GM103427","GM103471-09","1S10RR027754-01","S10 RR027754","P20 GM103471"],"pubmed_authors":["Cornish A","Gong Q","McKeithan T","Kucuk C","Hu X","Chan WC","Jiang B","Gaulard P"],"additional_accession":[]},"is_claimable":false,"name":"Diagnostic and Biological Significance of KIR Expression Profile Determined by RNA-Seq in Natural Killer/T-Cell Lymphoma.","description":"Natural killer/T-cell lymphoma (NKTCL) is a rare, aggressive form of non-Hodgkin lymphoma that is generally incurable at more advanced stages with systemic involvement. Clonal diagnostic markers (eg, unique T- or B-cell receptor rearrangements) are not available for NKTCLs. Killer cell immunoglobulin like receptors (KIRs) are a family of type I transmembrane glycoproteins involved in the inhibition or activation of NK cells. A restricted expression profile of KIRs has been proposed as clonal markers of NK-cell proliferations. Here we evaluated the transcription profile of all KIR family genes and C-type lectin receptor genes using RNA sequencing on NKTCL cases (n = 17) and NK-cell lines (n = 3). The expression of all KIRs tended to be markedly reduced or absent in NKTCL, except for the KIR","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jun","modification":"2026-05-29T23:04:31.972Z","creation":"2019-03-27T02:15:44Z"},"accession":"S-EPMC4901131","cross_references":{"pubmed":["27060228"],"doi":["10.1016/j.ajpath.2016.02.011"]}}