biostudies-literatureKucuk CNational Institute for General Medical ScienceNational Center for Research ResourcesNCRR NIH HHSNIH Lymphoma Specialized Programs of Research ExcellenceNCI NIH HHSNIGMS NIH HHS1435-41https://www.ebi.ac.uk/biostudies/studies/S-EPMC4901131biostudies-literatureUnknown186(6)Natural killer/T-cell lymphoma (NKTCL) is a rare, aggressive form of non-Hodgkin lymphoma that is generally incurable at more advanced stages with systemic involvement. Clonal diagnostic markers (eg, unique T- or B-cell receptor rearrangements) are not available for NKTCLs. Killer cell immunoglobulin like receptors (KIRs) are a family of type I transmembrane glycoproteins involved in the inhibition or activation of NK cells. A restricted expression profile of KIRs has been proposed as clonal markers of NK-cell proliferations. Here we evaluated the transcription profile of all KIR family genes and C-type lectin receptor genes using RNA sequencing on NKTCL cases (n = 17) and NK-cell lines (n = 3). The expression of all KIRs tended to be markedly reduced or absent in NKTCL, except for the KIRThe American journal of pathologyDiagnostic and Biological Significance of KIR Expression Profile Determined by RNA-Seq in Natural Killer/T-Cell Lymphoma.PMC4901131P20 RR016469P50 CA1073995P20RR016469P20 RR018788P50CA136411-01 (W.C.C.)P30 CA033572RR018788-08P50 CA1364118P20GM103427P20 GM103427GM103471-091S10RR027754-01S10 RR027754P20 GM103471Cornish AGong QMcKeithan TKucuk CHu XChan WCJiang BGaulard PfalseDiagnostic and Biological Significance of KIR Expression Profile Determined by RNA-Seq in Natural Killer/T-Cell Lymphoma.Natural killer/T-cell lymphoma (NKTCL) is a rare, aggressive form of non-Hodgkin lymphoma that is generally incurable at more advanced stages with systemic involvement. Clonal diagnostic markers (eg, unique T- or B-cell receptor rearrangements) are not available for NKTCLs. Killer cell immunoglobulin like receptors (KIRs) are a family of type I transmembrane glycoproteins involved in the inhibition or activation of NK cells. A restricted expression profile of KIRs has been proposed as clonal markers of NK-cell proliferations. Here we evaluated the transcription profile of all KIR family genes and C-type lectin receptor genes using RNA sequencing on NKTCL cases (n = 17) and NK-cell lines (n = 3). The expression of all KIRs tended to be markedly reduced or absent in NKTCL, except for the KIR2016-01-01T00:00:00Z2016 Jun2026-05-29T23:04:31.972Z2019-03-27T02:15:44ZS-EPMC49011312706022810.1016/j.ajpath.2016.02.011