{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(10)"],"submitter":["Zhang Y"],"pubmed_abstract":["Unlike many other human solid tumors, ovarian tumors express many epithelial markers at a high level for cell growth and local invasion. The phosphoprotein Pinin plays a key role in epithelial cell identity. We showed that clinical ovarian tumors and ovarian cancer cell lines express a high level of Pinin when compared with normal ovarian tissues and immortalized normal ovarian surface epithelial cell lines. Pinin co-localized and physically interacted with transcriptional corepressor C-terminal binding proteins, CtBP1 and CtBP2, in the nuclei of cancer cells. Knockdown of Pinin in ovarian cancer cells resulted in specific reduction of CtBP1 protein expression, cell adhesion, anchorage-independent growth, and increased drug sensitivity. Whole transcriptomic comparison of next-generation RN"],"journal":["Oncotarget"],"pagination":["11397-411"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4905481"],"repository":["biostudies-literature"],"pubmed_title":["Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells."],"pmcid":["PMC4905481"],"pubmed_authors":["Yang J","Sugrue SP","Liu M","Ng SK","Muto MG","Tsui SK","Choi PW","Kwok JS","Welch WR","Ng SW","Berkowitz RS","Zhang Y","Singh M"],"additional_accession":[]},"is_claimable":false,"name":"Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells.","description":"Unlike many other human solid tumors, ovarian tumors express many epithelial markers at a high level for cell growth and local invasion. The phosphoprotein Pinin plays a key role in epithelial cell identity. We showed that clinical ovarian tumors and ovarian cancer cell lines express a high level of Pinin when compared with normal ovarian tissues and immortalized normal ovarian surface epithelial cell lines. Pinin co-localized and physically interacted with transcriptional corepressor C-terminal binding proteins, CtBP1 and CtBP2, in the nuclei of cancer cells. Knockdown of Pinin in ovarian cancer cells resulted in specific reduction of CtBP1 protein expression, cell adhesion, anchorage-independent growth, and increased drug sensitivity. Whole transcriptomic comparison of next-generation RN","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Mar","modification":"2026-05-30T04:23:54.253Z","creation":"2019-03-27T02:15:54Z"},"accession":"S-EPMC4905481","cross_references":{"pubmed":["26871283"],"doi":["10.18632/oncotarget.7242"]}}