biostudies-literatureLawson RAMedical Research CouncilWellcome TrustParkinson's UK47-53https://www.ebi.ac.uk/biostudies/studies/S-EPMC4906150biostudies-literatureUnknown27<h4>Introduction</h4>Parkinson's disease dementia (PDD) is associated with poorer quality of life (QoL). Prior to the onset of PDD, many patients experience progressive cognitive impairment. There is a paucity of longitudinal studies investigating the effects of cognitive decline on QoL. This study aimed to determine the longitudinal impact of cognitive change on QoL in an incident PD cohort.<h4>Methods</h4>Recently diagnosed patients with PD (n = 212) completed a schedule of neuropsychological assessments and QoL measures; these were repeated after 18 (n = 190) and 36 months (n = 158). Mild cognitive impairment (PD-MCI) was classified with reference to the Movement Disorder Society criteria. Principal component analysis was used to reduce 10 neuropsychological tests to three cognitive facParkinsonism & related disordersCognitive decline and quality of life in incident Parkinson's disease: The role of attention.PMC4906150MC_U105597119103838/Z/14/ZJ-0802Duncan GWKhoo TKICICLE-PD study groupBreen DPWilliams-Gray CHTaylor JPLawson RACollerton DBurn DJBarker RAYarnall AJfalseCognitive decline and quality of life in incident Parkinson's disease: The role of attention.<h4>Introduction</h4>Parkinson's disease dementia (PDD) is associated with poorer quality of life (QoL). Prior to the onset of PDD, many patients experience progressive cognitive impairment. There is a paucity of longitudinal studies investigating the effects of cognitive decline on QoL. This study aimed to determine the longitudinal impact of cognitive change on QoL in an incident PD cohort.<h4>Methods</h4>Recently diagnosed patients with PD (n = 212) completed a schedule of neuropsychological assessments and QoL measures; these were repeated after 18 (n = 190) and 36 months (n = 158). Mild cognitive impairment (PD-MCI) was classified with reference to the Movement Disorder Society criteria. Principal component analysis was used to reduce 10 neuropsychological tests to three cognitive fac2016-01-01T00:00:00Z2016 Jun2025-04-19T23:17:44.202Z2019-03-27T02:15:56ZS-EPMC49061502709448210.1016/j.parkreldis.2016.04.009